Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.36 |
| ▸ | SLC16A3 | O15427 | 2/20 | 0.36 |
| ▸ | SLC16A1 | P53985 | 2/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | THRA | P10827 | 1/20 | 0.34 |
| ▸ | THRB | P10828 | 1/20 | 0.34 |
| ▸ | VCAM1 | P19320 | 2/20 | 0.33 |
| ▸ | KDR | P35968 | 1/20 | 0.33 |
| ▸ | ALDH3A1 | P30838 | 1/20 | 0.33 |
| ▸ | HCAR3 | P49019 | 2/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.32 |
| ▸ | AR | P10275 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3058223 | 0.90 | TDP1 (0.40) | MAPTCYP3A4MAPK1TDP1TSHR | |
| SCHEMBL3049451 | 0.88 | VCAM1 (0.40) | MAPTTDP1VCAM1SMN1; SMN2CYP19A1 | |
| SCHEMBL3045411 | 0.88 | MAPT (0.44) | MAPTCYP3A4MAPK1SLC16A3SLC16A1 | |
| SCHEMBL3050952 | 0.86 | MAPT (0.46) | MAPTCYP3A4MAPK1SLC16A3SLC16A1 | |
| SCHEMBL3049771 | 0.84 | TDP1 (0.46) | MAPTCYP3A4MAPK1TDP1TSHR | |
| SCHEMBL3055631 | 0.81 | MAPT (0.50) | MAPTCYP3A4MAPK1SLC16A3SLC16A1 | |
| SCHEMBL3058351 | 0.81 | VCAM1 (0.44) | MAPTCYP3A4MAPK1TDP1TSHR | |
| SCHEMBL5693113 | 0.80 | MAPT (0.39) | MAPTCYP3A4MAPK1SLC16A3SLC16A1 | |
| SCHEMBL3057818 | 0.79 | VCAM1 (0.47) | MAPTCYP3A4MAPK1SLC16A3SLC16A1 | |
| SCHEMBL5692257 | 0.78 | VCAM1 (0.36) | MAPTVCAM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1654221-A2 | ANILINE DERIVATIVED ANDROGEN-, GLUCOCORTICOID-, MINERALCORTICOID- AND PROGESTERONE- RECEPTOR MODULATORS | SMITHKLINE BEECHAM CORPORATION (US) | 2006-05-10 | — | — | EP | disclosed |
| WO-2005000795-A2 | ANILINE DERIVATIVED ANDROGEN-, GLUCOCORTICOID-, MINERALCORTICOID- AND PROGESTERONE- RECEPTOR MODULATORS | SMITHKLINE BEECHAM CORPORATION (US) | 2005-01-06 | — | — | WO | disclosed |