Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.39 |
| ▸ | PGR | P06401 | 6/20 | 0.38 |
| ▸ | VCAM1 | P19320 | 5/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.34 |
| ▸ | SLC16A3 | O15427 | 1/20 | 0.33 |
| ▸ | SLC16A1 | P53985 | 1/20 | 0.33 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.32 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.32 |
| ▸ | CRHR1 | P34998 | 1/20 | 0.32 |
| ▸ | TSHR | P16473 | 1/20 | 0.32 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3051207 | 0.83 | MAPT (0.52) | MAPTVCAM1LMNAPOLBMEN1 | |
| SCHEMBL3048933 | 0.82 | PGR (0.47) | PGRCYP2D6CYP2C9CRHR1 | |
| SCHEMBL3058223 | 0.81 | TDP1 (0.40) | MAPTVCAM1LMNAALDH1A1CYP3A4 | |
| SCHEMBL3058351 | 0.81 | VCAM1 (0.44) | MAPTVCAM1LMNAPOLBALDH1A1 | |
| SCHEMBL5692484 | 0.81 | VCAM1 (0.38) | PGRVCAM1KMT2AALDH1A1CYP3A4 | |
| SCHEMBL5692532 | 0.81 | PGR (0.43) | MAPTPGRVCAM1MEN1KMT2A | |
| SCHEMBL5692102 | 0.80 | MAPT (0.41) | MAPTVCAM1CYP3A4MAPK1SLC16A3 | |
| SCHEMBL3060094 | 0.79 | PGR (0.54) | PGRSLC16A3SLC16A1 | |
| SCHEMBL3057818 | 0.78 | VCAM1 (0.47) | MAPTVCAM1POLBALDH1A1CYP3A4 | |
| SCHEMBL3045411 | 0.78 | MAPT (0.44) | MAPTVCAM1ALDH1A1CYP3A4MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1654221-A2 | ANILINE DERIVATIVED ANDROGEN-, GLUCOCORTICOID-, MINERALCORTICOID- AND PROGESTERONE- RECEPTOR MODULATORS | SMITHKLINE BEECHAM CORPORATION (US) | 2006-05-10 | — | — | EP | disclosed |
| WO-2005000795-A2 | ANILINE DERIVATIVED ANDROGEN-, GLUCOCORTICOID-, MINERALCORTICOID- AND PROGESTERONE- RECEPTOR MODULATORS | SMITHKLINE BEECHAM CORPORATION (US) | 2005-01-06 | — | — | WO | disclosed |