Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.46 |
| ▸ | VCAM1 | P19320 | 5/20 | 0.40 |
| ▸ | HCAR3 | P49019 | 2/20 | 0.36 |
| ▸ | LMNA | P02545 | 2/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | ALDH3A1 | P30838 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | CYP19A1 | P11511 | 2/20 | 0.33 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.33 |
| ▸ | PIK3R1 | P27986 | 1/20 | 0.33 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.33 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.33 |
| ▸ | PGR | P06401 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5693121 | 0.92 | MAPT (0.46) | MAPTVCAM1HCAR3LMNAHTT | |
| SCHEMBL3057818 | 0.83 | VCAM1 (0.47) | MAPTVCAM1HCAR3ALDH3A1ALDH1A1 | |
| SCHEMBL3060338 | 0.81 | MAPT (0.60) | MAPTVCAM1HCAR3LMNAHTT | |
| SCHEMBL3054662 | 0.81 | VCAM1 (0.51) | MAPTVCAM1HCAR3LMNAALDH3A1 | |
| SCHEMBL3047731 | 0.77 | VCAM1 (0.48) | MAPTVCAM1ALDH3A1ALDH1A1CYP19A1 | |
| SCHEMBL3053986 | 0.76 | MAPT (0.50) | MAPTVCAM1HCAR3ALDH3A1ALDH1A1 | |
| SCHEMBL6819352 | 0.76 | MAPT (0.54) | MAPTVCAM1HCAR3LMNAHTT | |
| SCHEMBL3051050 | 0.75 | MAPT (0.50) | MAPTVCAM1HCAR3ALDH1A1 | |
| SCHEMBL5692492 | 0.75 | MAPT (0.42) | MAPTVCAM1HCAR3LMNAHTT | |
| SCHEMBL5692148 | 0.74 | VCAM1 (0.36) | MAPTVCAM1HCAR3LMNAALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1654221-A2 | ANILINE DERIVATIVED ANDROGEN-, GLUCOCORTICOID-, MINERALCORTICOID- AND PROGESTERONE- RECEPTOR MODULATORS | SMITHKLINE BEECHAM CORPORATION (US) | 2006-05-10 | — | — | EP | claimed |
| WO-2005000795-A2 | ANILINE DERIVATIVED ANDROGEN-, GLUCOCORTICOID-, MINERALCORTICOID- AND PROGESTERONE- RECEPTOR MODULATORS | SMITHKLINE BEECHAM CORPORATION (US) | 2005-01-06 | — | — | WO | claimed |