Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SDHB | P21912 | 2/20 | 0.41 |
| ▸ | TP53 | P04637 | 7/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.39 |
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.38 |
| ▸ | ECE1 | P42892 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.36 |
| ▸ | LMNA | P02545 | 2/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | ADORA3 | P0DMS8 | 2/20 | 0.36 |
| ▸ | HTR1A | P08908 | 2/20 | 0.36 |
| ▸ | HTR2C | P28335 | 2/20 | 0.36 |
| ▸ | HTR2A | P28223 | 1/20 | 0.36 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.36 |
| ▸ | HTR7 | P34969 | 1/20 | 0.36 |
| ▸ | HTR6 | P50406 | 1/20 | 0.36 |
| ▸ | STAT3 | P40763 | 2/20 | 0.36 |
| ▸ | STAT1 | P42224 | 2/20 | 0.36 |
| ▸ | HTT | P42858 | 2/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5690844 | 0.81 | TLR8 (0.38) | SMN1; SMN2TLR8ECE1KMT2ALMNA | |
| SCHEMBL5691603 | 0.80 | TLR8 (0.39) | SMN1; SMN2TLR8ECE1KMT2ALMNA | |
| SCHEMBL5363392 | 0.71 | THRB (0.37) | SDHBHPGDKDM4E | |
| SCHEMBL5691492 | 0.69 | ADORA3 (0.41) | SMN1; SMN2TLR8ECE1KMT2ALMNA | |
| SCHEMBL5691615 | 0.68 | ECE1 (0.38) | SMN1; SMN2TLR8ECE1KMT2AHTR1A | |
| SCHEMBL5691459 | 0.67 | ECE1 (0.49) | SMN1; SMN2TLR8ECE1LMNANPSR1 | |
| SCHEMBL5692010 | 0.65 | ECE1 (0.38) | SMN1; SMN2TLR8ECE1KMT2ALMNA | |
| SCHEMBL5690836 | 0.65 | ECE1 (0.50) | SMN1; SMN2TLR8ECE1KMT2ALMNA | |
| SCHEMBL13996908 | 0.61 | MEN1 (0.42) | KMT2AMAPTTDP1 | |
| SCHEMBL5367572 | 0.61 | KDM4E (0.40) | SDHBTP53SMN1; SMN2KMT2ALMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1644338-A1 | 2, 4, 6-TRISUBSTITUTED PYRIMIDINE DERIVATIVES USEFUL FOR THE TREATMENT OF NEOPLASTIC AND AUTOIMMUNE DISEASES | Aponetics AG (CH) | 2006-04-12 | — | — | EP | disclosed |
| WO-2004087679-A1 | 2, 4, 6-TRISUBSTITUTED PYRIMIDINE DERIVATIVES USEFUL FOR THE TREATMENT OF NEOPLASTIC AND AUTOIMMUNE DISEASES | APONETICS AG (CH) | 2004-10-14 | — | — | WO | disclosed |