Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.52 |
| ▸ | GAA | P10253 | 5/20 | 0.52 |
| ▸ | TSHR | P16473 | 4/20 | 0.52 |
| ▸ | LMNA | P02545 | 3/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.50 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.50 |
| ▸ | MAPT | P10636 | 3/20 | 0.50 |
| ▸ | MEN1 | O00255 | 3/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.50 |
| ▸ | GSR | P00390 | 2/20 | 0.50 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.50 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.50 |
| ▸ | BLM | P54132 | 2/20 | 0.50 |
| ▸ | ATM | Q13315 | 2/20 | 0.50 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.50 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.50 |
| ▸ | HPGD | P15428 | 2/20 | 0.50 |
| ▸ | HTT | P42858 | 1/20 | 0.50 |
| ▸ | GMNN | O75496 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9193491 | 0.89 | ALDH1A1 (0.52) | ALDH1A1GAATSHRLMNAKMT2A | |
| SCHEMBL284696 | 0.83 | ALDH1A1 (0.63) | ALDH1A1GAATSHRLMNAKMT2A | |
| SCHEMBL5693112 | 0.83 | ALDH1A1 (0.50) | ALDH1A1GAATSHRLMNAKMT2A | |
| SCHEMBL5609679 | 0.82 | ALDH1A1 (0.60) | ALDH1A1GAATSHRLMNAKMT2A | |
| SCHEMBL9190234 | 0.81 | ALDH1A1 (0.51) | ALDH1A1GAATSHRLMNAKMT2A | |
| SCHEMBL7520072 | 0.80 | ALDH1A1 (0.48) | ALDH1A1GAATSHRLMNAMAPK1 | |
| SCHEMBL8751536 | 0.79 | ALDH1A1 (0.59) | ALDH1A1GAATSHRLMNAKMT2A | |
| SCHEMBL283499 | 0.79 | ALDH1A1 (0.59) | ALDH1A1GAATSHRLMNAKMT2A | |
| SCHEMBL7530152 | 0.79 | GAA (0.48) | ALDH1A1GAATSHRLMNAKMT2A | |
| SCHEMBL5692085 | 0.79 | GAA (0.48) | ALDH1A1GAATSHRLMNAKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1468692-B1 | Use of 2,6-di-alkyl-4-silyl-phenols for treating xanthoma | MERRELL PHARMA INC (US) | 2006-04-26 | — | — | EP | disclosed |
| EP-0732928-B1 | METHOD OF LOWERING SERUM CHOLESTEROL LEVELS WITH 2,6-DI-ALKYL-4-SILYL-PHENOLS | MERRELL PHARMA INC (US) | 2004-12-22 | — | — | EP | disclosed |
| EP-1468693-A2 | Use of 2,6-di -alkyl-4-silyl-phenols for treating diabetes mellitus | MERRELL PHARMACEUTICALS INC. (US) | 2004-10-20 | — | — | EP | disclosed |
| EP-1468692-A2 | Use of 2,6-di-alkyl-4-silyl-phenols for treating xanthoma | MERRELL PHARMACEUTICALS INC. (US) | 2004-10-20 | — | — | EP | disclosed |
| US-5795876-A | ANTIINFLAMMATORY AGENTS | HOECHST MARION ROUSSSEL, INC. (US) | 1998-08-18 | — | — | US | disclosed |
| US-5532400-A | 2,6-di-alkyl-4-silyl-phenols as antiatheroscelerotic agents | MERRELL PHARMACEUTICALS INC. (US) | 1996-07-02 | — | — | US | disclosed |
| EP-0464852-B1 | Novel 2,6-di-alkyl-4-silyl-phenols as antiatherosclerotic agents and as antioxidants | MERRELL DOW PHARMA (US) | 1996-03-20 | — | — | EP | disclosed |
| US-5155250-A | 2,6-DI-ALKYL-4-SILYL-PHENOLS AS ANTIATHEROSCEROTIC AGENTS | MERRELL DOW PHARMACEUTICALS INC. (US) | 1992-10-13 | — | — | US | disclosed |
| EP-0464852-A1 | Novel 2,6-di-alkyl-4-silyl-phenols as antiatherosclerotic agents and as antioxidants | MERRELL PHARMACEUTICALS INC. (US) | 1992-01-08 | — | — | EP | disclosed |