Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 7/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.48 |
| ▸ | MEN1 | O00255 | 3/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.42 |
| ▸ | LMNA | P02545 | 3/20 | 0.42 |
| ▸ | TSHR | P16473 | 2/20 | 0.42 |
| ▸ | HTT | P42858 | 2/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.42 |
| ▸ | GSR | P00390 | 2/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | AGTR1 | P30556 | 1/20 | 0.42 |
| ▸ | GMNN | O75496 | 1/20 | 0.41 |
| ▸ | GABBR2 | O75899 | 1/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5692085 | 0.88 | GAA (0.48) | GAAKMT2AMEN1ALDH1A1LMNA | |
| SCHEMBL5692156 | 0.84 | GAA (0.47) | GAAKMT2AMEN1ALDH1A1LMNA | |
| SCHEMBL9193491 | 0.79 | ALDH1A1 (0.52) | GAAKMT2AMEN1ALDH1A1LMNA | |
| SCHEMBL5693103 | 0.79 | ALDH1A1 (0.52) | GAAKMT2AMEN1ALDH1A1LMNA | |
| SCHEMBL9855739 | 0.79 | GAA (0.57) | GAAKMT2AMEN1ALDH1A1LMNA | |
| SCHEMBL11578296 | 0.76 | GAA (0.54) | GAAKMT2AMEN1ALDH1A1LMNA | |
| SCHEMBL7520042 | 0.75 | CA2 (0.45) | GAAKMT2AMEN1ALDH1A1TSHR | |
| SCHEMBL284696 | 0.74 | ALDH1A1 (0.63) | GAAKMT2AMEN1ALDH1A1LMNA | |
| SCHEMBL5693112 | 0.74 | ALDH1A1 (0.50) | GAAKMT2AMEN1ALDH1A1LMNA | |
| SCHEMBL7518915 | 0.74 | GAA (0.43) | GAAKMT2AMEN1ALDH1A1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0900225-B1 | ALKYL-4-SILYL-PHENOLS AND ESTERS THEREOF AS ANTIATHEROSCLEROTIC AGENTS | AVENTIS PHARMA INC (US) | 2002-01-30 | — | — | EP | disclosed |
| US-5608095-A | Alkyl-4-silyl-phenols and esters thereof as antiatherosclerotic agents | HOECHST MARION ROUSSEL, INC. (US) | 1997-03-04 | — | — | US | disclosed |