Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.39 |
| ▸ | VCAM1 | P19320 | 2/20 | 0.35 |
| ▸ | PGR | P06401 | 1/20 | 0.31 |
| ▸ | AR | P10275 | 1/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.30 |
| ▸ | MEN1 | O00255 | 1/20 | 0.30 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.30 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.30 |
| ▸ | TSHR | P16473 | 1/20 | 0.30 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3040881 | 0.87 | VCAM1 (0.45) | MAPTCYP3A4MAPK1VCAM1PGR | |
| SCHEMBL3057864 | 0.87 | VCAM1 (0.36) | MAPTCYP3A4MAPK1VCAM1CYP19A1 | |
| SCHEMBL3053986 | 0.85 | MAPT (0.50) | MAPTCYP3A4MAPK1VCAM1KDM4E | |
| SCHEMBL3055631 | 0.85 | MAPT (0.50) | MAPTCYP3A4MAPK1VCAM1KDM4E | |
| SCHEMBL5693116 | 0.84 | AR (0.40) | MAPTCYP3A4MAPK1VCAM1PGR | |
| SCHEMBL5693115 | 0.84 | MAPT (0.40) | MAPTCYP3A4MAPK1VCAM1PGR | |
| SCHEMBL3045411 | 0.81 | MAPT (0.44) | MAPTCYP3A4MAPK1VCAM1CYP19A1 | |
| SCHEMBL3057818 | 0.81 | VCAM1 (0.47) | MAPTCYP3A4MAPK1VCAM1CYP19A1 | |
| SCHEMBL3050952 | 0.81 | MAPT (0.46) | MAPTCYP3A4MAPK1VCAM1CYP19A1 | |
| SCHEMBL5692532 | 0.79 | PGR (0.43) | MAPTCYP3A4MAPK1VCAM1PGR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1654221-A2 | ANILINE DERIVATIVED ANDROGEN-, GLUCOCORTICOID-, MINERALCORTICOID- AND PROGESTERONE- RECEPTOR MODULATORS | SMITHKLINE BEECHAM CORPORATION (US) | 2006-05-10 | — | — | EP | claimed |
| WO-2005000795-A2 | ANILINE DERIVATIVED ANDROGEN-, GLUCOCORTICOID-, MINERALCORTICOID- AND PROGESTERONE- RECEPTOR MODULATORS | SMITHKLINE BEECHAM CORPORATION (US) | 2005-01-06 | — | — | WO | claimed |