Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP11B1 | P15538 | 1/20 | 0.43 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.43 |
| ▸ | CNR2 | P34972 | 4/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | CCRL2 | O00421 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | NOD2 | Q9HC29 | 6/20 | 0.38 |
| ▸ | NOD1 | Q9Y239 | 6/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | KCNN4 | O15554 | 1/20 | 0.37 |
| ▸ | CETP | P11597 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4469205 | 0.78 | CYP11B1 (0.44) | CYP11B1CYP11B2CNR2ALDH1A1SMN1; SMN2 | |
| SCHEMBL4479204 | 0.76 | CYP11B1 (0.47) | CYP11B1CYP11B2CNR2ALDH1A1CCRL2 | |
| SCHEMBL19984873 | 0.70 | CYP11B1 (0.55) | CYP11B1CYP11B2 | |
| SCHEMBL31137134 | 0.70 | LMNA (0.43) | CYP11B1CYP11B2ALDH1A1LMNAKCNN4 | |
| SCHEMBL23271216 | 0.69 | IDO1 (0.52) | CYP11B1CYP11B2ALDH1A1CCRL2 | |
| SCHEMBL4473837 | 0.68 | CYP11B1 (0.42) | CYP11B1CYP11B2ALDH1A1NOD2NOD1 | |
| SCHEMBL10188552 | 0.68 | DGAT1 (0.46) | CYP11B1CYP11B2ALDH1A1CCRL2LMNA | |
| SCHEMBL27528481 | 0.67 | CYP11B1 (0.41) | CYP11B1CYP11B2ALDH1A1NOD2NOD1 | |
| SCHEMBL12631704 | 0.66 | NOTUM (0.49) | ALDH1A1SMN1; SMN2LMNAKDM4E | |
| SCHEMBL6111255 | 0.66 | CETP (0.48) | CYP11B1CYP11B2CCRL2CETP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1528923-B1 | N-((3-OXO-2,3-DIHYDRO-1H-ISOINDOL-1-YL)ACETYL)GUANIDINE DERIVATIVES AS NHE1-INHIBITORS FOR THE TREATMENT OF INFARCTION AND ANGINA PECTORIS | SANOFI AVENTIS DEUTSCHLAND (DE) | 2006-05-03 | — | — | EP | disclosed |