⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9583 | 0.81 | — | — | |
| SCHEMBL9384246 | 0.70 | TDP2 (0.42) | — | |
| SCHEMBL2004412 | 0.67 | — | — | |
| SCHEMBL2863 | 0.66 | — | — | |
| SCHEMBL5712063 | 0.64 | TRPA1 (0.30) | — | |
| SCHEMBL1036477 | 0.62 | — | — | |
| SCHEMBL240948 | 0.62 | — | — | |
| SCHEMBL12298859 | 0.62 | — | — | |
| SCHEMBL15618396 | 0.60 | PTPRC (0.38) | — | |
| SCHEMBL1271989 | 0.60 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 367 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3773552-A1 | COMPOUNDS FOR TREATING HUNTINGTON'S DISEASE | PTC Therapeutics, Inc. (US) | 2021-02-17 | — | — | EP | claimed |
| WO-2019191229-A1 | COMPOUNDS FOR TREATING HUNTINGTON'S DISEASE | PTC THERAPEUTICS, INC. (US) | 2019-10-03 | — | — | WO | claimed |
| EP-2809668-B1 | 4-(BENZOIMIDAZOL-2-YL)-THIAZOLE COMPOUNDS AND RELATED AZA DERIVATIVES | ACTELION PHARMACEUTICALS LTD (CH) | 2017-04-12 | — | — | EP | claimed |
| EP-2654748-B1 | INDAZOLE DERIVATIVES USEFUL AS ERK INHIBITORS | MERCK SHARP & DOHME (US) | 2016-07-27 | — | — | EP | claimed |
| US-9266876-B2 | 4-(benzoimidazol-2-yl)-thiazole compounds and related aza derivatives | ACTELION PHARMACEUTICALS LTD. (CH) | 2016-02-23 | — | — | US | claimed |
| US-20140371204-A1 | 4-(Benzoimidazol-2-yl)-thiazole Compounds and Related Aza Derivatives | IDORSIA PHARMACEUTICALS LTD (CH) | 2014-12-18 | — | — | US | claimed |
| EP-2809668-A1 | 4-(BENZOIMIDAZOL-2-YL)-THIAZOLE COMPOUNDS AND RELATED AZA DERIVATIVES | Actelion Pharmaceuticals Ltd. (CH) | 2014-12-10 | — | — | EP | claimed |
| US-8586623-B2 | 2-oxo-1-pyrrolidine derivatives, processes for preparing them and their uses | UCB PHARMA, S.A. (BE) | 2013-11-19 | — | — | US | claimed |
| EP-2654748-A1 | INDAZOLE DERIVATIVES USEFUL AS ERK INHIBITORS | Merck Sharp & Dohme Corp. (US) | 2013-10-30 | — | — | EP | claimed |
| US-20130261125-A1 | INDAZOLE DERIVATIVES USEFUL AS ERK INHIBITORS | MERCK SHARP & DOHME LLC | 2013-10-03 | — | — | US | claimed |
| WO-1998056800-A1 | 9-OXIME ERYTHROMYCIN DERIVATIVES | PFIZER PRODUCTS INC. (US) | 1998-12-17 | — | — | WO | claimed |
| WO-1998051696-A1 | ERYTHROMYCIN DERIVATIVES | PFIZER PRODUCTS INC. (US) | 1998-11-19 | — | — | WO | claimed |
| EP-0786460-A2 | 2-Arylquinolines and process for producing the same | ASAHI GLASS COMPANY LTD. (JP) | 1997-07-30 | — | — | EP | claimed |
| EP-0709377-A1 | Process for producing quinolin-2-yl benzoic acid compounds | ASAHI GLASS COMPANY LTD. (JP) | 1996-05-01 | — | — | EP | claimed |
| EP-0480204-B1 | Imidazole derivatives, potent and selective antagonists of angiotensin II receptor | FUJISAWA PHARMACEUTICAL CO (JP) | 1996-03-20 | — | — | EP | claimed |
| US-5444066-A | Thioformamide derivatives having hypotensive activity | EISAI CO., LTD. (JP) | 1995-08-22 | — | — | US | claimed |
| EP-0609442-A1 | THIOFORMAMIDE DERIVATIVE | Eisai Co., Ltd. (JP) | 1994-08-10 | — | — | EP | claimed |
| EP-0548553-A1 | Optically active azole compounds, their production and use | Takeda Chemical Industries, Ltd. (JP) | 1993-06-30 | — | — | EP | claimed |
| US-5215994-A | Treating or preventing hypertension or heart failure | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1993-06-01 | — | — | US | claimed |
| EP-0480204-A1 | Imidazole derivatives, potent and selective antagonists of angiotensin II receptor | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1992-04-15 | — | — | EP | claimed |