Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPV1 | Q8NER1 | 15/20 | 0.77 |
| ▸ | RAB9A | P51151 | 2/20 | 0.71 |
| ▸ | NPC1 | O15118 | 1/20 | 0.71 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.71 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.71 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.71 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.71 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.71 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.62 |
| ▸ | MEN1 | O00255 | 1/20 | 0.62 |
| ▸ | MAPT | P10636 | 1/20 | 0.62 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.62 |
| ▸ | TP53 | P04637 | 1/20 | 0.56 |
| ▸ | GFER | P55789 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6826358 | 0.94 | TRPV1 (0.74) | TRPV1RAB9ANPC1CYP1A2CYP3A4 | |
| SCHEMBL2747077 | 0.88 | NPC1 (0.71) | TRPV1RAB9ANPC1CYP1A2CYP3A4 | |
| SCHEMBL11726742 | 0.87 | TRPV1 (0.76) | TRPV1RAB9ANPC1CYP1A2CYP3A4 | |
| SCHEMBL11422447 | 0.87 | TRPV1 (1.00) | TRPV1RAB9ANPC1CYP1A2CYP3A4 | |
| SCHEMBL15782671 | 0.85 | TRPV1 (0.72) | TRPV1RAB9ANPC1CYP1A2CYP3A4 | |
| SCHEMBL12172779 | 0.84 | GFER (0.69) | TRPV1RAB9ANPC1KDM4EMEN1 | |
| SCHEMBL2676769 | 0.84 | TRPV1 (0.70) | TRPV1RAB9AKDM4EMEN1MAPT | |
| SCHEMBL4642544 | 0.84 | NPC1 (1.00) | RAB9ANPC1CYP1A2CYP3A4CYP2D6 | |
| SCHEMBL30184438 | 0.84 | NPC1 (1.00) | RAB9ANPC1CYP1A2CYP3A4CYP2D6 | |
| SCHEMBL1269411 | 0.83 | KDM4E (0.69) | TRPV1RAB9AKDM4EMEN1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 16 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20020019414-A1 | N-aryl(thio)anthranilic acid amide derivatives, their preparation and their use as VEGF receptor tyrosine kinase inhibitors | NOVARTIS AG (CH) | 2002-02-14 | — | — | US | claimed |
| JP-57058154-A | — | — | None | — | — | JP | disclosed |
| EP-1682181-A2 | COMBINATION OF A VEGF RECEPTOR INHIBITOR WITH A CHEMOTHERAPEUTIC AGENT | Novartis AG (CH) | 2006-07-26 | — | — | EP | disclosed |
| EP-1667721-A2 | COMBINATIONS OF A VEGF RECEPTOR INHIBITOR WITH OTHER THERAPEUTIC AGENTS | Novartis AG (CH) | 2006-06-14 | — | — | EP | disclosed |
| WO-2005027972-A2 | COMBINATION OF A VEGF RECEPTOR INHIBITOR WITH A CHEMOTHERAPEUTIC AGENT | NOVARTIS AG (CH) | 2005-03-31 | — | — | WO | disclosed |
| WO-2005027973-A2 | COMBINATIONS OF A VEGF RECEPTOR INHIBITOR WITH OTHER THERAPEUTIC AGENTS | NOVARTIS AG (CH) | 2005-03-31 | — | — | WO | disclosed |
| EP-0255643-B1 | METAL COMPLEX COMPOUND USEFUL AS A NEAR INFRARED ABSORBER | HODOGAYA CHEMICAL CO., LTD. (JP) | 1991-10-09 | — | — | EP | disclosed |
| US-4977249-A | FOR OPTICAL FILTERS OR SHIELDS | HODOGAYA CHEMICAL CO., LTD. (JP) | 1990-12-11 | — | — | US | disclosed |
| EP-0255643-A2 | Metal complex compound useful as a near infrared absorber | HODOGAYA CHEMICAL CO., LTD. (JP) | 1988-02-10 | — | — | EP | disclosed |
| US-4390611-A | Electrophotographic photosensitive azo pigment containing members | CANON KABUSHIKI KAISHA (JP) | 1983-06-28 | — | — | US | disclosed |
| JP-S5758154-A | ELECTROPHOTOGRAPHIC RECEPTOR | COPYER CO LTD | 1982-04-07 | — | — | JP | disclosed |
| US-4219473-A | Substituted unsymmetrical azo, azomethine 1:2 chromium complexes | CIBA-GEIGY CORPORATION (US) | 1980-08-26 | — | — | US | disclosed |
| US-4053462-A | UNSYMMETRICAL PHENYL AZO NAPHTHYL CHROMIUM COMPLEX DYES | CIBA-GEIGY CORPORATION (US) | 1977-10-11 | — | — | US | disclosed |
| US-4046752-A | Process for preparing an azo compound from a 2-aminothiazole diazo component | HOECHST AKTIENGESELLSCHAFT (DT) | 1977-09-06 | — | — | US | disclosed |
| US-4005065-A | GOOD FASTNESS TO LIGHT, PERSPIRATION, FULLING, DECATIZING AND CARBONIZING | CIBA-GEIGY CORPORATION (US) | 1977-01-25 | — | — | US | disclosed |
| US-3939142-A | Phenylazophenyl dyestuff | HOECHST AKTIENGESELLSCHAFT (DT) | 1976-02-17 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20020019414-A1 | N-aryl(thio)anthranilic acid amide derivatives, their preparation and their use as VEGF receptor tyrosine kinase inhibitors | AXL, TYRO3, KDR | TRPV1 3894/4885RAB9A 1026/4885NPC1 4229/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.