Sugi Predict

Sugi Predict / Compounds / SCHEMBL4642544

SCHEMBL4642544

SCHEMBL4642544

O=C(Nc1cccc2ccccc12)c1ccccc1

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ NPC1 O15118 4/20 1.00
▸ RAB9A P51151 4/20 1.00
▸ CYP1A2 P05177 1/20 1.00
▸ CYP3A4 P08684 1/20 1.00
▸ CYP2D6 P10635 1/20 1.00
▸ CYP2C9 P11712 1/20 1.00
▸ CYP2C19 P33261 1/20 1.00
▸ KMT2A Q03164 3/20 0.69
▸ KDM4E B2RXH2 3/20 0.65
▸ GAA P10253 1/20 0.65
▸ CHRNB2 P17787 1/20 0.62
▸ CHRNB4 P30926 1/20 0.62
▸ CHRNA3 P32297 1/20 0.62
▸ CHRNA4 P43681 1/20 0.62
▸ MAPT P10636 1/20 0.62
▸ ALOX5 P09917 1/20 0.61
▸ HSD17B10 Q99714 1/20 0.61
▸ EGFR P00533 1/20 0.61
▸ ERBB2 P04626 1/20 0.61
▸ PARP1 P09874 1/20 0.60

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL30184438 1.00 NPC1 (1.00) NPC1RAB9ACYP1A2CYP3A4CYP2D6
SCHEMBL3659724 0.91 RAB9A (0.84) NPC1RAB9ACYP1A2CYP3A4CYP2D6
SCHEMBL3148472 0.90 NPC1 (0.82) NPC1RAB9ACYP1A2CYP3A4CYP2D6
SCHEMBL26885232 0.89 NPC1 (0.81) NPC1RAB9ACYP1A2CYP3A4CYP2D6
SCHEMBL21914836 0.89 NPC1 (0.80) NPC1RAB9ACYP1A2CYP3A4CYP2D6
SCHEMBL27561288 0.89 RAB9A (0.79) NPC1RAB9ACYP1A2CYP3A4CYP2D6
SCHEMBL7539037 0.88 NPC1 (0.78) NPC1RAB9ACYP1A2CYP3A4CYP2D6
SCHEMBL26885585 0.88 RAB9A (0.77) NPC1RAB9ACYP1A2CYP3A4CYP2D6
SCHEMBL26889463 0.87 NPC1 (0.77) NPC1RAB9ACYP1A2CYP3A4CYP2D6
SCHEMBL3679744 0.86 RAB9A (0.76) NPC1RAB9ACYP1A2CYP3A4CYP2D6

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 98 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-118344283-A Trifluoromethyl unit-containing substituted 2-piperidone compound and synthesis method thereof 西南交通大学 2024-07-16 — — CN claimed
CN-117229483-A Amide potassium complex for catalyzing lactide ring-opening polymerization and preparation method thereof 北京服装学院 2023-12-15 — — CN claimed
CN-116660543-A Diagnostic and prognostic markers for nonalcoholic fatty liver disease and uses thereof 中国人民解放军陆军军医大学第一附属医院 2023-08-29 — — CN claimed
US-20210347752-A1 BENZAMIDE DERIVATIVES AS CGAS-STING PATHWAY AGONISTS BARUCH S. BLUMBERG INSTITUTE 2021-11-11 — — US claimed
CN-112888688-A Benzamide derivatives as CGAS-STING pathway agonists 巴鲁克斯布伦博格研究所 2021-06-01 — — CN claimed
WO-2020072492-A1 BENZAMIDE DERIVATIVES AS CGAS-STING PATHWAY AGONISTS BARUCH S. BLUMBERG INSTITUTE (US) 2020-04-09 — — WO claimed
CN-108358804-A The method that continuous high-efficient produces high purity N-substitution maleamic acid 四川大学 2018-08-03 — — CN claimed
CN-102719111-B Amido bond-containing 1, 8-naphthacenitrile fluorescent dichroic dye, and preparation method and application thereof UNIV DALIAN TECH 2013-12-25 — — CN claimed
CN-102719111-A Amido bond-containing 1, 8-naphthacenitrile fluorescent dichroic dye, and preparation method and application thereof UNIV DALIAN TECH 2012-10-10 — — CN claimed
EP-0620122-B1 Thermosensitive recording material NEW OJI PAPER CO LTD (JP) 1996-03-13 — — EP claimed
US-5446010-A Substrate sheet, thermosensitive colored image forming layer containing colorless dye precursor, binder, color developing agent having sulfonylureido group, aromatic amide sensitizer; storage stability NEW OJI PAPER CO., LTD. (JP) 1995-08-29 — — US claimed
EP-0620122-A1 Thermosensitive recording material NEW OJI PAPER CO., LTD. (JP) 1994-10-19 — — EP claimed
US-12509436-B2 Benzamide derivatives as cGAS-sting pathway agonists BARUCH S. BLUMBERG INSTITUTE (US) 2025-12-30 — — US disclosed
CN-118344283-A Trifluoromethyl unit-containing substituted 2-piperidone compound and synthesis method thereof 西南交通大学 2024-07-16 — — CN disclosed
CN-118048636-A Electrocatalytic synthesis method for N-aryl amide 平顶山学院 2024-05-17 — — CN disclosed
CN-117229483-A Amide potassium complex for catalyzing lactide ring-opening polymerization and preparation method thereof 北京服装学院 2023-12-15 — — CN disclosed
CN-85107531-A Process for producing vinyl chloride polymer — 1987-01-21 — — CN disclosed
EP-0172427-A2 Process for production of vinyl chloride polymer Shin-Etsu Chemical Co., Ltd. (JP) 1986-02-26 — — EP disclosed
US-4036978-A ANTIINFLAMMATORY AGENTS SANDOZ, INC. (US) 1977-07-19 — — US disclosed
US-3988364-A ANTITUSSIVE AGENTS TOYO JOZO KABUSHIKI KAISHA (JA) 1976-10-26 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-12509436-B2 Benzamide derivatives as cGAS-sting pathway agonists STING1, CGAS, IFNAR1 NPC1 633/4885RAB9A 370/4885CYP1A2 3405/4885
US-20210347752-A1 BENZAMIDE DERIVATIVES AS CGAS-STING PATHWAY AGONISTS STING1, CGAS, MAVS NPC1 1661/4885RAB9A 1646/4885CYP1A2 3730/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.