Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPV1 | Q8NER1 | 8/20 | 0.77 |
| ▸ | RAB9A | P51151 | 6/20 | 0.74 |
| ▸ | NPC1 | O15118 | 5/20 | 0.74 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.74 |
| ▸ | MAPT | P10636 | 2/20 | 0.67 |
| ▸ | MEN1 | O00255 | 1/20 | 0.65 |
| ▸ | CASP3 | P42574 | 1/20 | 0.65 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.65 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.65 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.65 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.65 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.63 |
| ▸ | GFER | P55789 | 1/20 | 0.63 |
| ▸ | GAA | P10253 | 2/20 | 0.62 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.60 |
| ▸ | TP53 | P04637 | 2/20 | 0.60 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.60 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.60 |
| ▸ | RELA | Q04206 | 1/20 | 0.60 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.59 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6055170 | 0.96 | TRPV1 (0.77) | TRPV1RAB9ANPC1SMN1; SMN2MAPT | |
| SCHEMBL5694495 | 0.91 | RAB9A (0.80) | TRPV1RAB9ANPC1SMN1; SMN2MAPT | |
| SCHEMBL4374092 | 0.88 | ALDH1A1 (0.64) | TRPV1RAB9ANPC1SMN1; SMN2MAPT | |
| SCHEMBL21652622 | 0.88 | RAB9A (0.78) | TRPV1RAB9ANPC1SMN1; SMN2MAPT | |
| Hydrochloric Acid SCHEMBL4366249 | 0.87 | ALDH1A1 (0.63) | TRPV1RAB9ANPC1SMN1; SMN2MAPT | |
| SCHEMBL8272789 | 0.87 | ALDH1A1 (0.63) | TRPV1RAB9ANPC1SMN1; SMN2MAPT | |
| SCHEMBL2864818 | 0.87 | ALDH1A1 (0.63) | TRPV1RAB9ANPC1SMN1; SMN2MAPT | |
| SCHEMBL2863763 | 0.87 | ALDH1A1 (0.63) | TRPV1RAB9ANPC1SMN1; SMN2MAPT | |
| SCHEMBL8252721 | 0.85 | RAB9A (1.00) | TRPV1RAB9ANPC1SMN1; SMN2MAPT | |
| SCHEMBL8867394 | 0.84 | RAB9A (0.72) | TRPV1RAB9ANPC1SMN1; SMN2MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1259487-A1 | 2-AMINO-NICOTINAMIDE DERIVATIVES AND THEIR USE AS VEGF-RECEPTOR TYROSINE KINASE INHIBITORS | Novartis AG (CH) | 2002-11-27 | — | — | EP | claimed |
| WO-2001055114-A1 | 2-AMINO-NICOTINAMIDE DERIVATIVES AND THEIR USE AS VEGF-RECEPTOR TYROSINE KINASE INHIBITORS | NOVARTIS AG (CH) | 2001-08-02 | — | — | WO | claimed |
| EP-1682181-A2 | COMBINATION OF A VEGF RECEPTOR INHIBITOR WITH A CHEMOTHERAPEUTIC AGENT | Novartis AG (CH) | 2006-07-26 | — | — | EP | disclosed |
| EP-1667721-A2 | COMBINATIONS OF A VEGF RECEPTOR INHIBITOR WITH OTHER THERAPEUTIC AGENTS | Novartis AG (CH) | 2006-06-14 | — | — | EP | disclosed |
| WO-2005027972-A2 | COMBINATION OF A VEGF RECEPTOR INHIBITOR WITH A CHEMOTHERAPEUTIC AGENT | NOVARTIS AG (CH) | 2005-03-31 | — | — | WO | disclosed |
| WO-2005027973-A2 | COMBINATIONS OF A VEGF RECEPTOR INHIBITOR WITH OTHER THERAPEUTIC AGENTS | NOVARTIS AG (CH) | 2005-03-31 | — | — | WO | disclosed |
| EP-1259487-A1 | 2-AMINO-NICOTINAMIDE DERIVATIVES AND THEIR USE AS VEGF-RECEPTOR TYROSINE KINASE INHIBITORS | Novartis AG (CH) | 2002-11-27 | — | — | EP | disclosed |
| WO-2001055114-A1 | 2-AMINO-NICOTINAMIDE DERIVATIVES AND THEIR USE AS VEGF-RECEPTOR TYROSINE KINASE INHIBITORS | NOVARTIS AG (CH) | 2001-08-02 | — | — | WO | disclosed |