Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA2A | P29274 | 7/20 | 0.58 |
| ▸ | PGK1 | P00558 | 3/20 | 0.58 |
| ▸ | PGK2 | P07205 | 3/20 | 0.58 |
| ▸ | NT5E | P21589 | 5/20 | 0.58 |
| ▸ | ADORA3 | P0DMS8 | 4/20 | 0.54 |
| ▸ | ADORA1 | P30542 | 3/20 | 0.53 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.53 |
| ▸ | THPO | P40225 | 1/20 | 0.53 |
| ▸ | TSHR | P16473 | 1/20 | 0.53 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5694961 | 1.00 | ADORA2A (0.58) | ADORA2APGK1PGK2NT5EADORA3 | |
| SCHEMBL6328795 | 0.91 | PGK1 (0.71) | ADORA2APGK1PGK2NT5EADORA3 | |
| SCHEMBL6328801 | 0.91 | PGK1 (0.71) | ADORA2APGK1PGK2NT5EADORA3 | |
| SCHEMBL5695127 | 0.89 | ADORA2A (0.72) | ADORA2ANT5EADORA3ADORA1ADORA2B | |
| SCHEMBL5695133 | 0.89 | ADORA2A (0.72) | ADORA2ANT5EADORA3ADORA1ADORA2B | |
| SCHEMBL7771098 | 0.87 | PGK1 (0.64) | ADORA2APGK1PGK2NT5EADORA3 | |
| SCHEMBL5694952 | 0.87 | PGK1 (0.64) | ADORA2APGK1PGK2NT5EADORA3 | |
| SCHEMBL5695048 | 0.85 | ADORA2A (0.74) | ADORA2ANT5EADORA3ADORA1ADORA2B | |
| SCHEMBL5695041 | 0.85 | ADORA2A (0.74) | ADORA2ANT5EADORA3ADORA1ADORA2B | |
| SCHEMBL5694948 | 0.84 | ADORA2A (0.81) | ADORA2APGK1PGK2NT5EADORA3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1121372-B1 | ADENINE DERIVATIVES | PFIZER LTD (GB) | 2006-06-28 | — | — | EP | disclosed |
| US-6326359-B1 | PURINE DERIVATIVES | PFIZER INC | 2001-12-04 | — | — | US | disclosed |