Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | LMNA | P02545 | 2/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | OPRM1 | P35372 | 5/20 | 0.42 |
| ▸ | SLC6A3 | Q01959 | 4/20 | 0.40 |
| ▸ | SLC6A2 | P23975 | 3/20 | 0.40 |
| ▸ | CHRM2 | P08172 | 2/20 | 0.40 |
| ▸ | HTR1A | P08908 | 2/20 | 0.40 |
| ▸ | ADRA2A | P08913 | 2/20 | 0.40 |
| ▸ | CHRM1 | P11229 | 2/20 | 0.40 |
| ▸ | DRD1 | P21728 | 2/20 | 0.40 |
| ▸ | TBXA2R | P21731 | 2/20 | 0.40 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.40 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.40 |
| ▸ | DRD3 | P35462 | 2/20 | 0.40 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.40 |
| ▸ | BCL2 | P10415 | 1/20 | 0.40 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6041278 | 0.74 | KMT2A (0.59) | ALDH1A1LMNAKMT2AMAPTOPRM1 | |
| SCHEMBL5695533 | 0.71 | SLC6A2 (0.45) | ALDH1A1LMNAKMT2AMAPTOPRM1 | |
| SCHEMBL6043390 | 0.68 | KMT2A (0.55) | ALDH1A1LMNAKMT2AMAPTOPRM1 | |
| SCHEMBL3591425 | 0.67 | CCR3 (0.57) | KMT2AOPRM1ADRA1AOPRL1OPRD1 | |
| SCHEMBL3444664 | 0.66 | OPRM1 (0.53) | ALDH1A1LMNAKMT2AMAPTOPRM1 | |
| SCHEMBL16565843 | 0.65 | OPRM1 (0.50) | ALDH1A1LMNAKMT2AMAPTOPRM1 | |
| SCHEMBL13563401 | 0.64 | MC4R (0.67) | ALDH1A1LMNAKMT2AOPRM1SLC6A3 | |
| SCHEMBL5962422 | 0.63 | OPRM1 (0.63) | ALDH1A1LMNAKMT2AOPRM1TSHR | |
| SCHEMBL31210281 | 0.63 | OPRM1 (0.59) | ALDH1A1LMNAKMT2AMAPTOPRM1 | |
| SCHEMBL31210280 | 0.63 | OPRM1 (0.59) | ALDH1A1LMNAKMT2AMAPTOPRM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1673358-A1 | PHENYLPIPERAZINE CYCLOALKANOL DERIVATIVES AND METHODS OF THEIR USE | Wyeth (US) | 2006-06-28 | — | — | EP | disclosed |
| WO-2005037808-A1 | PHENYLPIPERAZINE CYCLOALKANOL DERIVATIVES AND METHODS OF THEIR USE | WYETH (US) | 2005-04-28 | — | — | WO | disclosed |