Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A2 | P23975 | 2/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | OPRM1 | P35372 | 3/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | DRD2 | P14416 | 4/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | OPRL1 | P41146 | 2/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | CCR3 | P51677 | 1/20 | 0.41 |
| ▸ | CNR1 | P21554 | 1/20 | 0.40 |
| ▸ | HTR1A | P08908 | 1/20 | 0.39 |
| ▸ | DRD1 | P21728 | 1/20 | 0.39 |
| ▸ | DRD5 | P21918 | 1/20 | 0.39 |
| ▸ | HTR2A | P28223 | 1/20 | 0.39 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.39 |
| ▸ | HTR7 | P34969 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3444664 | 0.79 | OPRM1 (0.53) | SLC6A2ALDH1A1LMNAMAPTKMT2A | |
| SCHEMBL6041735 | 0.73 | KMT2A (0.57) | ALDH1A1LMNAMAPTKMT2AOPRM1 | |
| SCHEMBL5695532 | 0.71 | ALDH1A1 (0.43) | SLC6A2ALDH1A1LMNAMAPTKMT2A | |
| SCHEMBL3993473 | 0.69 | OPRM1 (0.53) | MAPTKMT2AOPRM1OPRL1TP53 | |
| SCHEMBL3821321 | 0.68 | OPRM1 (0.56) | ALDH1A1MAPTKMT2AOPRM1OPRL1 | |
| SCHEMBL3446137 | 0.68 | KMT2A (0.41) | SLC6A2KMT2AOPRM1OPRL1SLC6A4 | |
| SCHEMBL3444822 | 0.67 | SLC6A4 (0.44) | SLC6A2KMT2AOPRM1OPRL1SLC6A4 | |
| SCHEMBL3591425 | 0.67 | CCR3 (0.57) | KMT2AOPRM1DRD2OPRL1CCR3 | |
| SCHEMBL3444024 | 0.67 | SLC6A2 (0.46) | SLC6A2LMNAKMT2AOPRM1OPRL1 | |
| SCHEMBL3443526 | 0.67 | KMT2A (0.40) | SLC6A2KMT2AOPRM1OPRL1SLC6A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1673358-A1 | PHENYLPIPERAZINE CYCLOALKANOL DERIVATIVES AND METHODS OF THEIR USE | Wyeth (US) | 2006-06-28 | — | — | EP | disclosed |
| WO-2005037808-A1 | PHENYLPIPERAZINE CYCLOALKANOL DERIVATIVES AND METHODS OF THEIR USE | WYETH (US) | 2005-04-28 | — | — | WO | disclosed |