⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22856646 | 0.80 | LMNA (0.30) | — | |
| SCHEMBL26729915 | 0.80 | LMNA (0.30) | — | |
| SCHEMBL15128585 | 0.72 | — | — | |
| SCHEMBL7083160 | 0.71 | TSHR (0.42) | — | |
| SCHEMBL5691403 | 0.67 | TP53 (0.33) | — | |
| SCHEMBL5547703 | 0.67 | TP53 (0.33) | — | |
| SCHEMBL3273717 | 0.67 | TP53 (0.33) | — | |
| Isobutyramide SCHEMBL3323 | 0.66 | — | — | |
| Isobutyramide SCHEMBL11109750 | 0.66 | LMNA (0.46) | — | |
| SCHEMBL398674 | 0.65 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-104011209-A | Inhibition Of Viral Gene Expression | UNIV WITWATERSRAND JHB | 2014-08-27 | — | — | CN | disclosed |
| US-20070225285-A1 | 5-LIPOXYGENASE-ACTIVATING PROTEIN (FLAP) INHIBITORS | AMIRA PHARMACEUTICALS, INC. (US) | 2007-09-27 | — | — | US | disclosed |
| EP-1163250-B1 | IMPROVED SYNTHESIS OF ¬2.2.1|BICYCLO NUCLEOSIDES | EXIQON AS (DK) | 2006-07-12 | — | — | EP | disclosed |
| US-6734291-B2 | SULFONYLATION OF A DI(HYDROXYMETHANE)FURO(2,3-D)1,3-DIOXOLE DERIVATIVE WITH A SULFONYL HALIDE | EXIQON A/S (DK) | 2004-05-11 | — | — | US | disclosed |
| US-6639059-B1 | Novel synthesis strategy comprising novel key intermediate, (2.2.1)bicyclo nucleosides are produced at least two steps shorter than any previously known strategy; 3-O-aryl-4-C-hydroxymethyl-1,2-O-isopropylidene-alpha-D-ribofuranose | EXIQON A/S (DK) | 2003-10-28 | — | — | US | disclosed |
| US-20030092905-A1 | Synthesis of [2.2.1]bicyclo nucleosides | EXIQON A/S | 2003-05-15 | — | — | US | disclosed |
| EP-1163250-A2 | IMPROVED SYNTHESIS OF [2.2.1]BICYCLO NUCLEOSIDES | Exiqon A/S (DK) | 2001-12-19 | — | — | EP | disclosed |
| WO-2000056746-A2 | IMPROVED SYNTHESIS OF [2.2.1]BICYCLO NUCLEOSIDES | EXIQON A/S (US) | 2000-09-28 | — | — | WO | disclosed |