Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TTR | P02766 | 2/20 | 0.57 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | USP2 | O75604 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | DHFR | P00374 | 1/20 | 0.47 |
| ▸ | CA1 | P00915 | 1/20 | 0.47 |
| ▸ | CA2 | P00918 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | ALB | P02768 | 1/20 | 0.47 |
| ▸ | HMGB1 | P09429 | 1/20 | 0.47 |
| ▸ | HPGD | P15428 | 1/20 | 0.47 |
| ▸ | CXCL12 | P48061 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.47 |
| ▸ | SLC22A6 | Q4U2R8 | 1/20 | 0.47 |
| ▸ | ACMSD | Q8TDX5 | 1/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.47 |
| ▸ | KMO | O15229 | 2/20 | 0.44 |
| ▸ | KDM4A | O75164 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9728960 | 0.73 | ALB (0.56) | TTRKDM4EMEN1USP2ALDH1A1 | |
| SCHEMBL5380998 | 0.73 | TTR (1.00) | TTRKDM4EMEN1USP2ALDH1A1 | |
| SCHEMBL29377136 | 0.73 | TTR (1.00) | TTRKDM4EMEN1USP2ALDH1A1 | |
| SCHEMBL444742 | 0.72 | TTR (0.54) | TTRKDM4EMEN1USP2ALDH1A1 | |
| SCHEMBL21783789 | 0.71 | DPP4 (0.43) | KDM4EMEN1ALDH1A1CA1CA2 | |
| SCHEMBL4242281 | 0.70 | ALDH1A1 (0.55) | TTRKDM4EMEN1USP2ALDH1A1 | |
| SCHEMBL23539858 | 0.70 | TTR (0.55) | TTRKDM4EMEN1USP2ALDH1A1 | |
| SCHEMBL9135463 | 0.69 | ALDH1A1 (0.52) | TTRKDM4EMEN1USP2ALDH1A1 | |
| SCHEMBL10579578 | 0.68 | DHODH (0.67) | DHFRDHODH | |
| SCHEMBL19325620 | 0.68 | IDO1 (0.55) | TTRKDM4EMEN1USP2ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1679299-A1 | COMPOUNDS FOR THE TREATMENT OF DISEASES ASSOCIATED WITH THE FORMATION OF AMYLOID FIBRILS | Innovaprotean, S.L. (ES) | 2006-07-12 | — | — | EP | disclosed |