Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.59 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.59 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.59 |
| ▸ | LMNA | P02545 | 2/20 | 0.59 |
| ▸ | GAA | P10253 | 2/20 | 0.59 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.59 |
| ▸ | PKM | P14618 | 1/20 | 0.54 |
| ▸ | POLB | P06746 | 1/20 | 0.54 |
| ▸ | MEN1 | O00255 | 2/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.52 |
| ▸ | HPGD | P15428 | 1/20 | 0.52 |
| ▸ | PTGER4 | P35408 | 1/20 | 0.52 |
| ▸ | CTSV | O60911 | 1/20 | 0.52 |
| ▸ | CTSL | P07711 | 1/20 | 0.52 |
| ▸ | KDM6B | O15054 | 1/20 | 0.50 |
| ▸ | KDM4D | Q6B0I6 | 1/20 | 0.50 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.50 |
| ▸ | CASP3 | P42574 | 1/20 | 0.50 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.50 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5696409 | 0.88 | ALDH1A1 (0.63) | ALDH1A1KDM4ESMN1; SMN2LMNAGAA | |
| SCHEMBL19512045 | 0.87 | POLB (0.55) | ALDH1A1KDM4ESMN1; SMN2LMNAGAA | |
| SCHEMBL19511950 | 0.87 | MEN1 (0.63) | ALDH1A1KDM4ESMN1; SMN2GAAL3MBTL1 | |
| SCHEMBL2271181 | 0.85 | GAA (0.60) | ALDH1A1KDM4ESMN1; SMN2LMNAGAA | |
| SCHEMBL6407408 | 0.84 | MEN1 (0.66) | ALDH1A1KDM4ESMN1; SMN2LMNAGAA | |
| SCHEMBL27874817 | 0.83 | POLB (0.77) | ALDH1A1KDM4EGAAPOLBMEN1 | |
| SCHEMBL4040223 | 0.83 | ALDH1A1 (0.82) | ALDH1A1KDM4ESMN1; SMN2LMNAGAA | |
| SCHEMBL8044298 | 0.83 | ALDH1A1 (0.60) | ALDH1A1KDM4ESMN1; SMN2LMNAGAA | |
| SCHEMBL5696444 | 0.82 | ALDH1A1 (0.68) | ALDH1A1KDM4ESMN1; SMN2LMNAL3MBTL1 | |
| SCHEMBL14340794 | 0.82 | ALDH1A1 (0.63) | ALDH1A1KDM4ESMN1; SMN2LMNAL3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1670749-A1 | 2-SUBSTITUTED BENZOIC ACID DERIVATIVES AS HM74A RECEPTOR AGONISTS | SMITHKLINE BEECHAM CORPORATION (US) | 2006-06-21 | — | — | EP | disclosed |
| WO-2005016870-A1 | 2-SUBSTITUTED BENZOIC ACID DERIVATIVES AS HM74A RECEPTOR AGONISTS | SMITHKLINE BEECHAM CORPORATION (US) | 2005-02-24 | — | — | WO | disclosed |