Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.63 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.63 |
| ▸ | NPC1 | O15118 | 4/20 | 0.58 |
| ▸ | RAB9A | P51151 | 4/20 | 0.58 |
| ▸ | HPGD | P15428 | 1/20 | 0.58 |
| ▸ | PABPC1 | P11940 | 1/20 | 0.55 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.54 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.54 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.52 |
| ▸ | HTR3A | P46098 | 1/20 | 0.52 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.52 |
| ▸ | POLB | P06746 | 1/20 | 0.52 |
| ▸ | HTT | P42858 | 1/20 | 0.52 |
| ▸ | GAA | P10253 | 1/20 | 0.51 |
| ▸ | MEN1 | O00255 | 1/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.51 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.50 |
| ▸ | AADAT | Q8N5Z0 | 1/20 | 0.47 |
| ▸ | ATM | Q13315 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1501954 | 0.81 | SMN1; SMN2 (0.51) | ALDH1A1SMN1; SMN2NPC1RAB9AHPGD | |
| SCHEMBL14365992 | 0.81 | ALDH1A1 (0.54) | ALDH1A1SMN1; SMN2PABPC1MAPK1KDM4E | |
| SCHEMBL5697246 | 0.81 | ALDH1A1 (0.68) | ALDH1A1SMN1; SMN2NPC1RAB9AHPGD | |
| SCHEMBL809534 | 0.81 | PREP (0.57) | SMN1; SMN2NPC1RAB9AKDM4ENPSR1 | |
| SCHEMBL11486774 | 0.81 | ALDH1A1 (0.60) | ALDH1A1SMN1; SMN2NPC1RAB9APABPC1 | |
| Hydrochloric Acid SCHEMBL29680182 | 0.80 | ALDH1A1 (0.53) | ALDH1A1SMN1; SMN2NPC1RAB9AHPGD | |
| SCHEMBL11478559 | 0.78 | SMN1; SMN2 (0.65) | ALDH1A1SMN1; SMN2NPC1RAB9APABPC1 | |
| SCHEMBL5259296 | 0.78 | ALDH1A1 (1.00) | ALDH1A1SMN1; SMN2NPC1RAB9APABPC1 | |
| SCHEMBL1697463 | 0.78 | ALDH1A1 (1.00) | ALDH1A1SMN1; SMN2NPC1RAB9APABPC1 | |
| SCHEMBL8243019 | 0.78 | NPC1 (0.54) | ALDH1A1NPC1RAB9AHPGDKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1680400-A2 | DERIVATIVES OF N-[ PHENYL(PYRROLIDINE-2-YL)METHYL]BENZAMIDE AND N-[ (AZEPAN-2-YL)PHENYLMETHYL]BENZAMIDE, PREPARATION METHOD THEREOF AND APPLICATION OF SAME IN THERAPEUTICS | Sanofi-Aventis (FR) | 2006-07-19 | — | — | EP | disclosed |
| WO-2005037785-A2 | DERIVATIVES OF N-[PHENYL(PYRROLIDINE-2-YL)METHYL]BENZAMIDE AND N-[(AZEPAN-2-YL)PHENYLMETHYL]BENZAMIDE, PREPARATION METHOD THEREOF AND APPLICATION OF SAME IN THERAPEUTICS | SANOFI-AVENTIS (FR) | 2005-04-28 | — | — | WO | disclosed |