Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 11/20 | 0.58 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.55 |
| ▸ | THRB | P10828 | 1/20 | 0.54 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.52 |
| ▸ | POLB | P06746 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.47 |
| ▸ | HPGD | P15428 | 2/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | RAF1 | P04049 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | NR3C2 | P08235 | 5/20 | 0.44 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.44 |
| ▸ | PGR | P06401 | 1/20 | 0.44 |
| ▸ | AR | P10275 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4293610 | 0.89 | RXFP1 (0.63) | MAPTKMT2ATHRBRXFP1POLB | |
| SCHEMBL5139733 | 0.81 | KMT2A (0.53) | MAPTKMT2ATHRBRXFP1POLB | |
| SCHEMBL6168835 | 0.79 | MAPT (0.53) | MAPTKMT2ATHRBRXFP1POLB | |
| SCHEMBL5697055 | 0.78 | MAPT (0.53) | MAPTKMT2ATHRBRXFP1POLB | |
| SCHEMBL5697047 | 0.76 | HTT (0.51) | MAPTKMT2ATHRBMEN1 | |
| SCHEMBL4258401 | 0.74 | ACLY (0.48) | MAPTRAF1NR3C2PGR | |
| SCHEMBL4271505 | 0.74 | MAPT (0.74) | MAPTKMT2ATHRBRXFP1POLB | |
| SCHEMBL304764 | 0.73 | MAPT (0.62) | MAPTKMT2ARXFP1ALDH1A1HPGD | |
| SCHEMBL24508666 | 0.73 | CYP3A4 (0.58) | MAPTKMT2APOLBALDH1A1 | |
| SCHEMBL4294282 | 0.72 | RXFP1 (0.59) | MAPTKMT2ATHRBRXFP1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1656367-A1 | 4- (HETEROCYCLYL- FUSED PHENYL)- 3- (PHENYL OR PYRID -2- YL) PYRAZOLES AS INHIBITORS OF THE ALK-5- RECEPTOR | SmithKline Beecham Corporation (US) | 2006-05-17 | — | — | EP | claimed |
| WO-2004111036-A1 | 4- (HETEROCYCLYL- FUSED PHENYL)- 3- (PHENYL OR PYRID -2- YL) PYRAZOLES AS INHIBITORS OF THE ALK-5- RECEPTOR | SMITHKLINE BEECHAM CORPORATION (US) | 2004-12-23 | — | — | WO | claimed |
| EP-1656367-A1 | 4- (HETEROCYCLYL- FUSED PHENYL)- 3- (PHENYL OR PYRID -2- YL) PYRAZOLES AS INHIBITORS OF THE ALK-5- RECEPTOR | SmithKline Beecham Corporation (US) | 2006-05-17 | — | — | EP | disclosed |
| WO-2004111036-A1 | 4- (HETEROCYCLYL- FUSED PHENYL)- 3- (PHENYL OR PYRID -2- YL) PYRAZOLES AS INHIBITORS OF THE ALK-5- RECEPTOR | SMITHKLINE BEECHAM CORPORATION (US) | 2004-12-23 | — | — | WO | disclosed |