Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 11/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.53 |
| ▸ | THRB | P10828 | 1/20 | 0.49 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | NR3C2 | P08235 | 3/20 | 0.44 |
| ▸ | PGR | P06401 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.43 |
| ▸ | HPGD | P15428 | 2/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.42 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.42 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6168732 | 0.79 | KMT2A (0.51) | MAPTKMT2ATHRBRXFP1POLB | |
| SCHEMBL6167811 | 0.79 | KMT2A (0.55) | MAPTKMT2ATHRBRXFP1NR3C2 | |
| SCHEMBL5697173 | 0.79 | MAPT (0.58) | MAPTKMT2ATHRBRXFP1POLB | |
| SCHEMBL6621746 | 0.74 | POLB (0.52) | MAPTKMT2APOLBNR3C2ALDH1A1 | |
| SCHEMBL4271505 | 0.74 | MAPT (0.74) | MAPTKMT2ATHRBRXFP1POLB | |
| SCHEMBL5697055 | 0.72 | MAPT (0.53) | MAPTKMT2ATHRBRXFP1POLB | |
| SCHEMBL28270660 | 0.72 | IDO1 (0.58) | MAPTNPC1RAB9ASMN1; SMN2 | |
| SCHEMBL30015279 | 0.72 | MMP12 (0.65) | MAPTKMT2ATHRBPOLBNR3C2 | |
| SCHEMBL302933 | 0.72 | MMP12 (0.65) | MAPTKMT2ATHRBPOLBNR3C2 | |
| SCHEMBL304764 | 0.71 | MAPT (0.62) | MAPTKMT2ARXFP1NR3C2PGR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20050165011-A1 | Benzoxazine and benzoxazinone substituted triazoles | GELLIBERT FRANCOISE J (FR) | 2005-07-28 | — | — | US | claimed |
| EP-1506191-A1 | BENZOXAZINE AND BENZOXAZINONE SUBSTITUTED TRIAZOLES | SMITHKLINE BEECHAM CORPORATION (US) | 2005-02-16 | — | — | EP | claimed |
| US-20050014938-A1 | Phenyl substituted triazoles and their use as selective inhibitors of akl5 kinase | GASTER LARAMIE MARY (GB) | 2005-01-20 | — | — | US | claimed |
| WO-2003097639-A1 | BENZOXAZINE AND BENZOXAZINONE SUBSTITUTED TRIAZOLES | SMITHKLINE BEECHAM CORPORATION (US) | 2003-11-27 | — | — | WO | claimed |
| US-20050165011-A1 | Benzoxazine and benzoxazinone substituted triazoles | GELLIBERT FRANCOISE J (FR) | 2005-07-28 | — | — | US | disclosed |
| EP-1506191-A1 | BENZOXAZINE AND BENZOXAZINONE SUBSTITUTED TRIAZOLES | SMITHKLINE BEECHAM CORPORATION (US) | 2005-02-16 | — | — | EP | disclosed |
| US-20050014938-A1 | Phenyl substituted triazoles and their use as selective inhibitors of akl5 kinase | GASTER LARAMIE MARY (GB) | 2005-01-20 | — | — | US | disclosed |
| WO-2003097639-A1 | BENZOXAZINE AND BENZOXAZINONE SUBSTITUTED TRIAZOLES | SMITHKLINE BEECHAM CORPORATION (US) | 2003-11-27 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050014938-A1 | Phenyl substituted triazoles and their use as selective inhibitors of akl5 kinase | AKR1C3, CBR3, PHKG1 | MAPT 4591/4885KMT2A 2230/4885THRB 983/4885 |
| US-20050165011-A1 | Benzoxazine and benzoxazinone substituted triazoles | ACVR1, TGFBR1, SMAD3 | MAPT 1751/4885KMT2A 3214/4885THRB 216/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.