Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.36 |
| ▸ | CASP1 | P29466 | 1/20 | 0.36 |
| ▸ | CASP7 | P55210 | 1/20 | 0.36 |
| ▸ | GPR55 | Q9Y2T6 | 1/20 | 0.36 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.33 |
| ▸ | LMNA | P02545 | 2/20 | 0.33 |
| ▸ | CA12 | O43570 | 1/20 | 0.33 |
| ▸ | CA1 | P00915 | 1/20 | 0.33 |
| ▸ | CA2 | P00918 | 1/20 | 0.33 |
| ▸ | CA9 | Q16790 | 1/20 | 0.33 |
| ▸ | MITF | O75030 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1140103 | 0.77 | ALDH1A1 (0.41) | KDM4ECYP2C9KMT2AALDH1A1LMNA | |
| SCHEMBL483343 | 0.77 | ALDH1A1 (0.43) | MAPK1KDM4ECYP2C9SMN1; SMN2KMT2A | |
| SCHEMBL4061705 | 0.75 | ALDH1A1 (0.42) | KDM4ESMN1; SMN2KMT2AALDH1A1LMNA | |
| SCHEMBL5051601 | 0.75 | CA12 (0.46) | TSHRMAPK1KDM4ECYP2C9SMN1; SMN2 | |
| SCHEMBL8558659 | 0.73 | ALDH1A1 (0.45) | TSHRGPR55KMT2AALDH1A1CA12 | |
| SCHEMBL757988 | 0.73 | ALDH1A1 (0.55) | TSHRMAPK1NPSR1KDM4EGPR55 | |
| SCHEMBL11406873 | 0.72 | CA12 (0.49) | TSHRMAPK1KDM4ECYP1A2SMN1; SMN2 | |
| SCHEMBL6312091 | 0.72 | ALDH1A1 (0.44) | MAPK1NPSR1KDM4ESMN1; SMN2ALDH1A1 | |
| SCHEMBL11512411 | 0.72 | ALDH1A1 (0.53) | TSHRMAPK1NPSR1KDM4EGPR55 | |
| Formaldehyde SCHEMBL4557832 | 0.72 | ALDH1A1 (0.53) | TSHRMAPK1NPSR1KDM4EGPR55 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1663192-A1 | ERG CHANNEL OPENERS FOR THE TREATMENT OF CARDIAC ARRHYTHMIAS | Poseidon Pharmaceuticals A/S (DK) | 2006-06-07 | — | — | EP | disclosed |
| WO-2005023238-A1 | ERG CHANNEL OPENERS FOR THE TREATMENT OF HYPEREXCITABILITY-RELATED NEURONAL DISEASES | POSEIDON PHARMACEUTICALS A/S (DK) | 2005-03-17 | — | — | WO | disclosed |
| WO-2005023237-A1 | ERG CHANNEL OPENERS FOR THE TREATMENT OF CARDIAC ARRHYTHMIAS | POSEIDON PHARMACEUTICALS A/S (DK) | 2005-03-17 | — | — | WO | disclosed |
| US-4008211-A | Betainic azo dyestuffs containing cobalt in complex union with a colorless, tridentate ligand | CIBA-GEIGY AG (CH) | 1977-02-15 | — | — | US | disclosed |