Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPV1 | Q8NER1 | 11/20 | 0.57 |
| ▸ | RAB9A | P51151 | 3/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.53 |
| ▸ | NAMPT | P43490 | 1/20 | 0.53 |
| ▸ | MEN1 | O00255 | 2/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.51 |
| ▸ | LMNA | P02545 | 1/20 | 0.51 |
| ▸ | NPC1 | O15118 | 2/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5697444 | 0.85 | TRPV1 (0.57) | TRPV1RAB9ASMN1; SMN2NAMPTMEN1 | |
| SCHEMBL2303319 | 0.84 | RAB9A (0.72) | TRPV1RAB9ASMN1; SMN2NAMPTMEN1 | |
| SCHEMBL14051568 | 0.78 | KCNQ3 (0.74) | RAB9ASMN1; SMN2NAMPTNPC1 | |
| SCHEMBL3121622 | 0.74 | HTT (0.63) | TRPV1RAB9ASMN1; SMN2NAMPTMEN1 | |
| SCHEMBL2303956 | 0.73 | KMT2A (0.66) | RAB9ASMN1; SMN2MEN1KMT2AALDH1A1 | |
| SCHEMBL5934750 | 0.73 | TRPV1 (1.00) | TRPV1 | |
| SCHEMBL3135086 | 0.72 | KCNQ3 (0.86) | TRPV1RAB9ASMN1; SMN2MEN1KMT2A | |
| SCHEMBL5934587 | 0.72 | TRPV1 (0.77) | TRPV1RAB9ANAMPTNPC1 | |
| SCHEMBL3309155 | 0.72 | PPARG (0.60) | RAB9ASMN1; SMN2MEN1KMT2AALDH1A1 | |
| SCHEMBL3881001 | 0.71 | TRPV1 (1.00) | TRPV1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1673342-A2 | AMIDES THAT INHIBIT VANILLOID RECEPROT SUBTYPE 1 (VR1) RECEPTOR | ABBOTT LABORATORIES (US) | 2006-06-28 | — | — | EP | disclosed |
| WO-2005040121-A2 | AMIDES THAT INHIBIT VANILLOID RECEPTOR SUBTYPE 1 (VR1) RECEPTOR | ABBOTT LABORATORIES (US) | 2005-05-06 | — | — | WO | disclosed |