Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARG | P37231 | 1/20 | 0.60 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.60 |
| ▸ | NCOR2 | Q9Y618 | 1/20 | 0.60 |
| ▸ | KMT2A | Q03164 | 8/20 | 0.57 |
| ▸ | MEN1 | O00255 | 7/20 | 0.57 |
| ▸ | RAB9A | P51151 | 6/20 | 0.57 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.57 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.57 |
| ▸ | HTT | P42858 | 2/20 | 0.57 |
| ▸ | NR2F2 | P24468 | 1/20 | 0.57 |
| ▸ | MAPT | P10636 | 3/20 | 0.57 |
| ▸ | GAA | P10253 | 1/20 | 0.57 |
| ▸ | POLB | P06746 | 2/20 | 0.55 |
| ▸ | P4HTM | Q9NXG6 | 1/20 | 0.55 |
| ▸ | LMNA | P02545 | 1/20 | 0.55 |
| ▸ | KCNQ3 | O43525 | 1/20 | 0.55 |
| ▸ | KCNQ2 | O43526 | 1/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.54 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.54 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1499710 | 0.89 | MAPT (0.70) | PPARGRXFP1NCOR2KMT2AMEN1 | |
| SCHEMBL2302302 | 0.87 | RAB9A (0.72) | KMT2AMEN1RAB9ASMN1; SMN2MAPK1 | |
| SCHEMBL3313663 | 0.86 | LMNA (0.58) | KMT2AMEN1RAB9ASMN1; SMN2MAPK1 | |
| SCHEMBL3312213 | 0.85 | POLB (0.49) | KMT2AMEN1RAB9ASMN1; SMN2MAPK1 | |
| SCHEMBL3312211 | 0.83 | KCNQ3 (0.62) | KMT2AMEN1RAB9ASMN1; SMN2HTT | |
| SCHEMBL3309149 | 0.83 | LMNA (0.58) | KMT2AMEN1RAB9ASMN1; SMN2MAPK1 | |
| SCHEMBL5697444 | 0.80 | TRPV1 (0.57) | KMT2AMEN1RAB9ASMN1; SMN2LMNA | |
| SCHEMBL3309586 | 0.80 | MEN1 (0.55) | PPARGNCOR2KMT2AMEN1RAB9A | |
| SCHEMBL14096398 | 0.77 | RAB9A (0.70) | KMT2AMEN1RAB9ASMN1; SMN2MAPK1 | |
| SCHEMBL15528742 | 0.77 | KDM4E (0.71) | PPARGRXFP1NCOR2KMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100113782-A1 | Diacylglycerol Acyltransferase Inhibitors | MADRIGAL PHARMACEUTICALS, INC. | 2010-05-06 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100113782-A1 | Diacylglycerol Acyltransferase Inhibitors | DGAT2, DGAT1, MOGAT2 | PPARG 227/4885RXFP1 3724/4885NCOR2 1479/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.