Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPV1 | Q8NER1 | 4/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | RORC | P51449 | 2/20 | 0.47 |
| ▸ | ADH5 | P11766 | 1/20 | 0.45 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.44 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.44 |
| ▸ | PDE4A | P27815 | 1/20 | 0.43 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.43 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.43 |
| ▸ | RARG | P13631 | 1/20 | 0.43 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.43 |
| ▸ | MAP2K4 | P45985 | 1/20 | 0.43 |
| ▸ | CAMKK2 | Q96RR4 | 1/20 | 0.43 |
| ▸ | CDH1 | P12830 | 1/20 | 0.42 |
| ▸ | APC | P25054 | 1/20 | 0.42 |
| ▸ | CTNNB1 | P35222 | 1/20 | 0.42 |
| ▸ | TCF7L2 | Q9NQB0 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3874091 | 0.94 | TRPV1 (0.56) | TRPV1SMN1; SMN2LMNARORCADH5 | |
| SCHEMBL10324285 | 0.81 | TRPV1 (0.56) | TRPV1RORCMKNK1MKNK2KDM4E | |
| SCHEMBL4174567 | 0.80 | CA12 (0.49) | SMN1; SMN2LMNAADH5MKNK1MKNK2 | |
| Hydrochloric Acid SCHEMBL6364365 | 0.80 | TRPV1 (0.54) | TRPV1RORCKDM4EMAP2K4NPC1 | |
| SCHEMBL14083508 | 0.77 | RAB9A (0.70) | TRPV1SMN1; SMN2KDM4ENPC1RAB9A | |
| SCHEMBL6873637 | 0.76 | KDM4E (0.56) | SMN1; SMN2LMNAMKNK1MKNK2PDE4A | |
| SCHEMBL14083467 | 0.75 | TRPV1 (0.75) | TRPV1SMN1; SMN2LMNANPC1RAB9A | |
| SCHEMBL14083872 | 0.75 | TRPV1 (0.63) | TRPV1SMN1; SMN2NPC1RAB9A | |
| SCHEMBL15330922 | 0.75 | ERN1 (0.47) | SMN1; SMN2MKNK1MKNK2PDE4APDE4C | |
| SCHEMBL14082841 | 0.74 | TRPV1 (0.77) | TRPV1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1673342-A2 | AMIDES THAT INHIBIT VANILLOID RECEPROT SUBTYPE 1 (VR1) RECEPTOR | ABBOTT LABORATORIES (US) | 2006-06-28 | — | — | EP | disclosed |
| WO-2005040121-A2 | AMIDES THAT INHIBIT VANILLOID RECEPTOR SUBTYPE 1 (VR1) RECEPTOR | ABBOTT LABORATORIES (US) | 2005-05-06 | — | — | WO | disclosed |