Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.52 |
| ▸ | TSHR | P16473 | 2/20 | 0.52 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.52 |
| ▸ | TP53 | P04637 | 1/20 | 0.52 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.50 |
| ▸ | POLB | P06746 | 1/20 | 0.50 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.47 |
| ▸ | KDM4A | O75164 | 1/20 | 0.46 |
| ▸ | HRH4 | Q9H3N8 | 6/20 | 0.46 |
| ▸ | HRH3 | Q9Y5N1 | 3/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | HPGD | P15428 | 2/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | HRH1 | P35367 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5909264 | 0.83 | L3MBTL1 (0.48) | LMNATSHRHSP90AA1TP53ALOX15 | |
| SCHEMBL17433947 | 0.76 | KMT2A (0.51) | LMNATSHRHSP90AA1TP53ALOX15 | |
| SCHEMBL9356625 | 0.74 | HSP90AA1 (0.57) | LMNATSHRHSP90AA1TP53ALOX15 | |
| SCHEMBL23742757 | 0.74 | L3MBTL1 (0.48) | LMNATSHRHSP90AA1TP53ALOX15 | |
| SCHEMBL31395167 | 0.74 | HRH4 (0.53) | LMNATSHRTP53ALOX15KMT2A | |
| SCHEMBL1156444 | 0.72 | LMNA (0.77) | LMNATSHRHSP90AA1TP53ALOX15 | |
| SCHEMBL21666388 | 0.72 | POLB (0.53) | LMNATSHRHSP90AA1TP53ALOX15 | |
| SCHEMBL13503827 | 0.71 | KMT2A (0.88) | LMNATSHRHSP90AA1TP53ALOX15 | |
| SCHEMBL6578719 | 0.71 | POLB (0.60) | LMNATSHRHSP90AA1TP53ALOX15 | |
| SCHEMBL20327780 | 0.71 | SMN1; SMN2 (0.39) | ALOX15KMT2APOLBL3MBTL1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1667990-A2 | NEW COMPOUNDS | AstraZeneca AB (SE) | 2006-06-14 | — | — | EP | disclosed |
| WO-2005027823-A2 | 3-HETEROCYCLYL-INDOLE DERIVATIVES AS INHIBITORS OF GLYCOGEN SYNTHASE KINASE-3 (GSK-3) | ASTRAZENECA AB (SE) | 2005-03-31 | — | — | WO | disclosed |