Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Bicarbonate. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A1 | P30531 | 4/20 | 0.43 |
| ▸ | SLC6A11 | P48066 | 3/20 | 0.43 |
| ▸ | SLC6A13 | Q9NSD5 | 3/20 | 0.43 |
| ▸ | TSHR | P16473 | 2/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | GABRA5 | P31644 | 3/20 | 0.42 |
| ▸ | GABRB2 | P47870 | 3/20 | 0.42 |
| ▸ | SLC6A12 | P48065 | 2/20 | 0.42 |
| ▸ | GABRA1 | P14867 | 2/20 | 0.42 |
| ▸ | GABRA4 | P48169 | 2/20 | 0.42 |
| ▸ | GABRR1 | P24046 | 1/20 | 0.42 |
| ▸ | GABRP | O00591 | 1/20 | 0.39 |
| ▸ | GABRD | O14764 | 1/20 | 0.39 |
| ▸ | GABRB1 | P18505 | 1/20 | 0.39 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.39 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.39 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.39 |
| ▸ | GABRA2 | P47869 | 1/20 | 0.39 |
| ▸ | GABRE | P78334 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8017282 | 0.88 | ALDH1A1 (0.47) | SLC6A1SLC6A11SLC6A13TSHRLMNA | |
| SCHEMBL1037842 | 0.88 | ALDH1A1 (0.47) | SLC6A1SLC6A11SLC6A13TSHRLMNA | |
| SCHEMBL1037843 | 0.88 | ALDH1A1 (0.47) | SLC6A1SLC6A11SLC6A13TSHRLMNA | |
| SCHEMBL6426932 | 0.88 | ALDH1A1 (0.47) | SLC6A1SLC6A11SLC6A13TSHRLMNA | |
| SCHEMBL165540 | 0.88 | ALDH1A1 (0.47) | SLC6A1SLC6A11SLC6A13TSHRLMNA | |
| SCHEMBL24912524 | 0.88 | ALDH1A1 (0.47) | SLC6A1SLC6A11SLC6A13TSHRLMNA | |
| SCHEMBL14772 | 0.88 | ALDH1A1 (0.47) | SLC6A1SLC6A11SLC6A13TSHRLMNA | |
| SCHEMBL14620877 | 0.88 | ALDH1A1 (0.47) | SLC6A1SLC6A11SLC6A13TSHRLMNA | |
| SCHEMBL22540086 | 0.88 | ALDH1A1 (0.47) | SLC6A1SLC6A11SLC6A13TSHRLMNA | |
| SCHEMBL5114077 | 0.88 | ALDH1A1 (0.47) | SLC6A1SLC6A11SLC6A13TSHRLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1670766-A1 | BICYCLIC IMINO ACID DERIVATIVES USED AS INHIBITORS OF MATRIX-METALLOPROTEINASES | Sanofi-Aventis Deutschland GmbH (DE) | 2006-06-21 | — | — | EP | disclosed |
| WO-2005030728-A1 | BICYCLIC IMINO ACID DERIVATIVES USED AS INHIBITORS OF MATRIX-METALLOPROTEINASES | SANOFI-AVENTIS DEUTSCHLAND GMBH (DE) | 2005-04-07 | — | — | WO | disclosed |