Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACE | P12821 | 9/20 | 0.41 |
| ▸ | EPHX1 | P07099 | 4/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.30 |
| ▸ | NAAA | Q02083 | 1/20 | 0.30 |
| ▸ | MEN1 | O00255 | 1/20 | 0.30 |
| ▸ | NPC1 | O15118 | 1/20 | 0.30 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5698079 | 0.88 | ACE (0.39) | ACE | |
| SCHEMBL5698075 | 0.88 | ACE (0.39) | ACE | |
| SCHEMBL5698100 | 0.87 | ACE (0.40) | ACELMNASMN1; SMN2 | |
| SCHEMBL7940360 | 0.85 | ACE (0.34) | ACEMAPTSMN1; SMN2NAAANPC1 | |
| SCHEMBL5698248 | 0.84 | ACE (0.46) | ACEMAPTSMN1; SMN2NAAA | |
| SCHEMBL5698134 | 0.84 | ACE (0.46) | ACEMAPTSMN1; SMN2NAAA | |
| SCHEMBL8027389 | 0.84 | SPHK1 (0.35) | ACE | |
| SCHEMBL5698108 | 0.79 | ACE (0.39) | ACE | |
| SCHEMBL5698147 | 0.78 | ACE (0.39) | ACE | |
| SCHEMBL5698090 | 0.69 | ACE (0.38) | ACESMN1; SMN2NAAAKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0979817-B1 | LEUKOTRIENE A4 HYDROLAZE INHIBITORS | SANTEN PHARMACEUTICAL CO LTD (JP) | 2006-07-26 | — | — | EP | claimed |
| US-6242476-B1 | Leukotriene A4 hydrolase inhibitors | SANTEN PHARMACEUTICAL CO., LTD. (JP) | 2001-06-05 | — | — | US | claimed |
| EP-0979817-A1 | LEUKOTRIENE A 4? HYDROLAZE INHIBITORS | SANTEN PHARMACEUTICAL CO., LTD. (JP) | 2000-02-16 | — | — | EP | claimed |
| EP-0979817-B1 | LEUKOTRIENE A4 HYDROLAZE INHIBITORS | SANTEN PHARMACEUTICAL CO LTD (JP) | 2006-07-26 | — | — | EP | disclosed |
| US-6242476-B1 | Leukotriene A4 hydrolase inhibitors | SANTEN PHARMACEUTICAL CO., LTD. (JP) | 2001-06-05 | — | — | US | disclosed |
| EP-0979817-A1 | LEUKOTRIENE A 4? HYDROLAZE INHIBITORS | SANTEN PHARMACEUTICAL CO., LTD. (JP) | 2000-02-16 | — | — | EP | disclosed |