Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACE | P12821 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
| ▸ | HPGD | P15428 | 2/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5698075 | 0.81 | ACE (0.39) | ACE | |
| SCHEMBL5698079 | 0.81 | ACE (0.39) | ACE | |
| SCHEMBL5698100 | 0.80 | ACE (0.40) | ACEALDH1A1 | |
| SCHEMBL5698086 | 0.79 | ACE (0.41) | ACE | |
| SCHEMBL7940360 | 0.78 | ACE (0.34) | ACEALDH1A1HPGD | |
| SCHEMBL5698134 | 0.77 | ACE (0.46) | ACEALDH1A1 | |
| SCHEMBL8027389 | 0.77 | SPHK1 (0.35) | ACE | |
| SCHEMBL5698248 | 0.77 | ACE (0.46) | ACEALDH1A1 | |
| SCHEMBL5698147 | 0.75 | ACE (0.39) | ACEALDH1A1 | |
| SCHEMBL11228772 | 0.70 | SLC6A2 (0.34) | ALDH1A1POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0979817-B1 | LEUKOTRIENE A4 HYDROLAZE INHIBITORS | SANTEN PHARMACEUTICAL CO LTD (JP) | 2006-07-26 | — | — | EP | disclosed |
| US-6242476-B1 | Leukotriene A4 hydrolase inhibitors | SANTEN PHARMACEUTICAL CO., LTD. (JP) | 2001-06-05 | — | — | US | disclosed |
| EP-0979817-A1 | LEUKOTRIENE A 4? HYDROLAZE INHIBITORS | SANTEN PHARMACEUTICAL CO., LTD. (JP) | 2000-02-16 | — | — | EP | disclosed |