SCHEMBL5698459

SCHEMBL5698459

CC(=O)C(=Cc1ccc(N(C)C)cc1)c1ccncc1

nearest known ligand 0.53

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MPO P05164 1/20 0.53
MAPT P10636 9/20 0.51
KMT2A Q03164 6/20 0.51
MEN1 O00255 5/20 0.51
SMN1; SMN2 Q16637 2/20 0.51
NPC1 O15118 2/20 0.51
RAB9A P51151 2/20 0.51
ALOX15 P16050 1/20 0.51
CASP1 P29466 1/20 0.51
HBB P68871 1/20 0.51
ALDH1A1 P00352 6/20 0.50
LMNA P02545 2/20 0.50
GAA P10253 2/20 0.50
GFER P55789 2/20 0.48
KDM4E B2RXH2 1/20 0.48
HDAC3 O15379 1/20 0.46
HDAC4 P56524 1/20 0.46
HDAC1 Q13547 1/20 0.46
HDAC7 Q8WUI4 1/20 0.46
HDAC2 Q92769 1/20 0.46

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5698449 1.00 MPO (0.53) MPOMAPTKMT2AMEN1SMN1; SMN2
SCHEMBL5698531 0.81 AKR1C3 (0.49) MAPTKMT2AMEN1SMN1; SMN2RAB9A
SCHEMBL5698524 0.81 AKR1C3 (0.49) MAPTKMT2AMEN1SMN1; SMN2RAB9A
SCHEMBL5253679 0.81 AKR1C1 (0.55) MAPTKMT2AMEN1ALDH1A1LMNA
SCHEMBL5253681 0.81 AKR1C1 (0.55) MAPTKMT2AMEN1ALDH1A1LMNA
SCHEMBL5698436 0.79 AKR1C3 (0.57) MAPTKMT2AMEN1SMN1; SMN2RAB9A
SCHEMBL5698441 0.79 AKR1C3 (0.57) MAPTKMT2AMEN1SMN1; SMN2RAB9A
SCHEMBL7176261 0.78 CYP19A1 (0.58) MAPTKMT2AMEN1ALDH1A1LMNA
SCHEMBL5698547 0.78 CYP19A1 (0.58) MAPTKMT2AMEN1ALDH1A1LMNA
SCHEMBL7176266 0.78 CYP19A1 (0.58) MAPTKMT2AMEN1ALDH1A1LMNA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1682143-A2 COMBINATIONS COMPRISING AN HSP90 INHIBITOR AND A PHOPHODIESTERASE INHIBITOR FOR TREATING OR PREVENTING NEOPLASIA Pharmacia Corporation (US) 2006-07-26 EP disclosed
WO-2005044194-A2 TREATMENT OR PREVENTION OF NEOPLASIA BY USE OF AN Hsp90 INHIBITOR PHARMACIA CORPORATION (US) 2005-05-19 WO disclosed
WO-2005041879-A2 COMBINATIONS COMPRISING AN Hsp90 INHIBITOR AND A PHOPHODIESTERASE INHIBITOR FOR TREATING OR PREVENTING NEOPLASIA PHARMACIA CORPORATION (US) 2005-05-12 WO disclosed