SCHEMBL5698632

SCHEMBL5698632

FS(F)(F)N(c1ccccc1)c1ccccc1

nearest known ligand 0.43

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
PKM P14618 1/20 0.43
ESR1 P03372 1/20 0.40
ALDH1A1 P00352 5/20 0.36
NPSR1 Q6W5P4 1/20 0.36
ALOX15 P16050 1/20 0.36
KMT2A Q03164 3/20 0.35
MAPT P10636 2/20 0.35
L3MBTL1 Q9Y468 2/20 0.35
MEN1 O00255 2/20 0.35
HTT P42858 2/20 0.35
KDM4E B2RXH2 1/20 0.35
CYP1A2 P05177 1/20 0.35
CYP3A4 P08684 1/20 0.35
CYP2D6 P10635 1/20 0.35
CYP2C9 P11712 1/20 0.35
CYP2C19 P33261 1/20 0.35
TDP1 Q9NUW8 1/20 0.35
TSHR P16473 1/20 0.34
MAPK1 P28482 1/20 0.34
HSD17B10 Q99714 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7021362 0.86 TSHR (0.42) PKMESR1ALDH1A1ALOX15KMT2A
SCHEMBL5500613 0.78 PKM (0.50) PKMESR1ALDH1A1NPSR1ALOX15
SCHEMBL5698408 0.74 CA12 (0.47) KMT2AL3MBTL1MEN1HTTKDM4E
SCHEMBL129629 0.73 PKM (0.56) PKMESR1ALDH1A1NPSR1ALOX15
SCHEMBL20851656 0.69 PKM (0.46) PKMESR1ALDH1A1NPSR1ALOX15
SCHEMBL13096335 0.67 PKM (0.45) PKMESR1ALDH1A1NPSR1ALOX15
SCHEMBL5698455 0.67 TSHR (0.53) ESR1ALDH1A1KMT2AMAPTL3MBTL1
SCHEMBL1704542 0.67 PKM (0.50) PKMESR1ALDH1A1NPSR1ALOX15
SCHEMBL11595292 0.67 PKM (0.50) PKMESR1ALDH1A1NPSR1ALOX15
SCHEMBL10632559 0.67 PKM (0.50) PKMESR1ALDH1A1NPSR1ALOX15

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1275631-B1 Fluorination with aminosulfur trifluorides AIR PROD & CHEM (US) 2006-07-19 EP disclosed
EP-1095934-B1 Process for the synthesis of dialkyl, diaryl, and arylalkyl aminosulphur trifluorides AIR PROD & CHEM (US) 2004-03-03 EP disclosed
EP-1275631-A2 Fluorination with aminosulfur trifluorides AIR PRODUCTS AND CHEMICALS, INC. (US) 2003-01-15 EP disclosed
EP-0908448-B1 Thermally stable aminosulfur trifluorides AIR PROD & CHEM (US) 2001-11-14 EP disclosed
US-6242645-B1 BIOLOGICAL ACTIVITY ENHANCER, DEOXOFLUORINATION AGENT OF INTEREST IN MEDICINAL AND AGROCHEMICAL PRODUCTS AIR PRODUCTS AND CHEMICALS, INC. 2001-06-05 US disclosed
EP-1095934-A1 Process for the synthesis of dialkyl, diaryl, and arylalkyl aminosulphur trifluorides AIR PRODUCTS AND CHEMICALS, INC. (US) 2001-05-02 EP disclosed
US-6222064-B1 PERFORMING FLUORINATION BY CONTACTING ALCOHOLS, ALDEHYDES, KETONES, EPOXIDES, AND MIXTURES USING A FLUORINATING REAGENT COMPRISING AMINOSULFUR TRIFLUORIDE COMPOUND AIR PRODUCTS AND CHEMICALS, INC. 2001-04-24 US disclosed
US-6207860-B1 FLUORINATING AGENTS, FAR LESS POTENTIAL OF VIOLENT DECOMPOSITION AND ATTENDANT HIGH GASEOUS BY-PRODUCT EVOLVEMENT, USEFUL FOR DEOXOFLUORINATION OF ALCOHOLS AND KETONES, AIR PRODUCTS AND CHEMICALS, INC. 2001-03-27 US disclosed
US-6096922-A REACTING A SECONDARY AMINE WITH SF.SUB.4 UNDER CONDITIONS SUCH THAT SAID AMINOSULFUR TRIFLUORIDE AND A LIQUID AMINE-HF ADDUCT ARE PRODUCED. AIR PRODUCTS AND CHEMICALS, INC. (US) 2000-08-01 US disclosed
US-6080886-A STABLE, EFFICIENT FLUORINATION WITH LESS POTENTIAL OF VIOLENT DECOMPOSITION AND ATTENDANT HIGH GASEOUS BY-PRODUCT EVOLVEMENT; PRODUCING SYNTHETIC DRUGS AND AGROCHEMICAL PRODUCTS AIR PRODUCTS AND CHEMICALS, INC. (US) 2000-06-27 US disclosed
EP-0908448-A1 Thermally stable aminosulfur trifluorides AIR PRODUCTS AND CHEMICALS, INC. (US) 1999-04-14 EP disclosed
EP-0905109-A1 Fluorination with aminosulfur trifluorides AIR PRODUCTS AND CHEMICALS, INC. (US) 1999-03-31 EP disclosed