Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX5 | P09917 | 4/20 | 0.74 |
| ▸ | MAPK11 | Q15759 | 3/20 | 0.74 |
| ▸ | MAPK14 | Q16539 | 3/20 | 0.74 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.74 |
| ▸ | CSNK1A1 | P48729 | 1/20 | 0.74 |
| ▸ | CSNK1D | P48730 | 1/20 | 0.74 |
| ▸ | CSNK1E | P49674 | 1/20 | 0.74 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.74 |
| ▸ | CSNK1A1L | Q8N752 | 1/20 | 0.74 |
| ▸ | MAPK13 | O15264 | 2/20 | 0.70 |
| ▸ | MAPK12 | P53778 | 2/20 | 0.70 |
| ▸ | GCGR | P47871 | 1/20 | 0.70 |
| ▸ | TEK | Q02763 | 1/20 | 0.66 |
| ▸ | PTGS2 | P35354 | 5/20 | 0.64 |
| ▸ | PTGS1 | P23219 | 4/20 | 0.64 |
| ▸ | NOX1 | Q9Y5S8 | 1/20 | 0.60 |
| ▸ | TP53 | P04637 | 2/20 | 0.55 |
| ▸ | MAPT | P10636 | 2/20 | 0.55 |
| ▸ | RAF1 | P04049 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11082212 | 0.89 | MAPK13 (0.87) | ALOX5MAPK11MAPK14ALDH1A1CSNK1A1 | |
| SCHEMBL4336547 | 0.85 | MAPK14 (1.00) | ALOX5MAPK11MAPK14ALDH1A1CSNK1A1 | |
| SCHEMBL458366 | 0.85 | MAPK14 (1.00) | ALOX5MAPK11MAPK14ALDH1A1CSNK1A1 | |
| SCHEMBL5698563 | 0.85 | ALOX5 (0.78) | ALOX5MAPK11MAPK14ALDH1A1CSNK1A1 | |
| SCHEMBL9201148 | 0.85 | MAPK14 (1.00) | ALOX5MAPK11MAPK14ALDH1A1CSNK1A1 | |
| Hydrochloric Acid SCHEMBL16566835 | 0.84 | MAPK14 (0.98) | ALOX5MAPK11MAPK14ALDH1A1CSNK1A1 | |
| SCHEMBL7484511 | 0.84 | ALOX5 (0.76) | ALOX5MAPK11MAPK14ALDH1A1CSNK1A1 | |
| SCHEMBL2648503 | 0.83 | MAPK11 (1.00) | ALOX5MAPK11MAPK14ALDH1A1CSNK1A1 | |
| SCHEMBL8008805 | 0.82 | NOX1 (0.85) | ALOX5MAPK11MAPK14ALDH1A1SMN1; SMN2 | |
| SCHEMBL15400824 | 0.82 | NOX1 (0.85) | ALOX5MAPK11MAPK14ALDH1A1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1682143-A2 | COMBINATIONS COMPRISING AN HSP90 INHIBITOR AND A PHOPHODIESTERASE INHIBITOR FOR TREATING OR PREVENTING NEOPLASIA | Pharmacia Corporation (US) | 2006-07-26 | — | — | EP | disclosed |
| WO-2005044194-A2 | TREATMENT OR PREVENTION OF NEOPLASIA BY USE OF AN Hsp90 INHIBITOR | PHARMACIA CORPORATION (US) | 2005-05-19 | — | — | WO | disclosed |
| WO-2005041879-A2 | COMBINATIONS COMPRISING AN Hsp90 INHIBITOR AND A PHOPHODIESTERASE INHIBITOR FOR TREATING OR PREVENTING NEOPLASIA | PHARMACIA CORPORATION (US) | 2005-05-12 | — | — | WO | disclosed |