Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX5 | P09917 | 8/20 | 0.74 |
| ▸ | MAPK13 | O15264 | 16/20 | 0.71 |
| ▸ | MAPK12 | P53778 | 16/20 | 0.71 |
| ▸ | MAPK11 | Q15759 | 16/20 | 0.71 |
| ▸ | MAPK14 | Q16539 | 16/20 | 0.71 |
| ▸ | GCGR | P47871 | 15/20 | 0.71 |
| ▸ | PRKD3 | O94806 | 2/20 | 0.71 |
| ▸ | MAP4K4 | O95819 | 2/20 | 0.71 |
| ▸ | FRK | P42685 | 2/20 | 0.71 |
| ▸ | MAPK9 | P45984 | 2/20 | 0.71 |
| ▸ | CSNK1A1 | P48729 | 2/20 | 0.71 |
| ▸ | CSNK1D | P48730 | 2/20 | 0.71 |
| ▸ | GSK3B | P49841 | 2/20 | 0.71 |
| ▸ | PTK6 | Q13882 | 2/20 | 0.71 |
| ▸ | CLK4 | Q9HAZ1 | 2/20 | 0.71 |
| ▸ | PRKD2 | Q9BZL6 | 1/20 | 0.71 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.70 |
| ▸ | CIT | O14578 | 1/20 | 0.70 |
| ▸ | GAK | O14976 | 1/20 | 0.70 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.70 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4552840 | 1.00 | ALOX5 (0.74) | ALOX5MAPK13MAPK12MAPK11MAPK14 | |
| SCHEMBL2648968 | 0.86 | MAPK14 (0.72) | ALOX5MAPK13MAPK12MAPK11MAPK14 | |
| SCHEMBL4553131 | 0.85 | ALOX5 (1.00) | ALOX5MAPK13MAPK12MAPK11MAPK14 | |
| SCHEMBL15075603 | 0.84 | MAPK11 (1.00) | ALOX5MAPK13MAPK12MAPK11MAPK14 | |
| SCHEMBL19868925 | 0.84 | MAPK11 (1.00) | ALOX5MAPK13MAPK12MAPK11MAPK14 | |
| Sb-202190 SCHEMBL158854 | 0.83 | MAPK13 (1.00) | ALOX5MAPK13MAPK12MAPK11MAPK14 | |
| SCHEMBL9195650 | 0.83 | MAPK13 (1.00) | ALOX5MAPK13MAPK12MAPK11MAPK14 | |
| Sb-202190 SCHEMBL3386753 | 0.83 | MAPK13 (1.00) | ALOX5MAPK13MAPK12MAPK11MAPK14 | |
| SCHEMBL2648930 | 0.83 | MAPK13 (1.00) | ALOX5MAPK13MAPK12MAPK11MAPK14 | |
| SCHEMBL6465326 | 0.82 | MAPK13 (0.74) | ALOX5MAPK13MAPK12MAPK11MAPK14 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1682143-A2 | COMBINATIONS COMPRISING AN HSP90 INHIBITOR AND A PHOPHODIESTERASE INHIBITOR FOR TREATING OR PREVENTING NEOPLASIA | Pharmacia Corporation (US) | 2006-07-26 | — | — | EP | disclosed |
| WO-2005044194-A2 | TREATMENT OR PREVENTION OF NEOPLASIA BY USE OF AN Hsp90 INHIBITOR | PHARMACIA CORPORATION (US) | 2005-05-19 | — | — | WO | disclosed |
| WO-2005041879-A2 | COMBINATIONS COMPRISING AN Hsp90 INHIBITOR AND A PHOPHODIESTERASE INHIBITOR FOR TREATING OR PREVENTING NEOPLASIA | PHARMACIA CORPORATION (US) | 2005-05-12 | — | — | WO | disclosed |