Sb-202190

Sb-202190

SCHEMBL3386753

Oc1ccc(-c2nc(-c3ccncc3)c(-c3ccc(F)cc3)[nH]2)cc1

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Full drug profile on Sugi Atlas →

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MAPK13 O15264 15/20 1.00
MAPK12 P53778 15/20 1.00
MAPK11 Q15759 15/20 1.00
MAPK14 Q16539 15/20 1.00
GCGR P47871 13/20 1.00
ALOX5 P09917 12/20 1.00
PRKD3 O94806 3/20 1.00
MAP4K4 O95819 3/20 1.00
FRK P42685 3/20 1.00
MAPK9 P45984 3/20 1.00
CSNK1A1 P48729 3/20 1.00
CSNK1D P48730 3/20 1.00
GSK3B P49841 3/20 1.00
CLK4 Q9HAZ1 3/20 1.00
PTK6 Q13882 2/20 1.00
RAF1 P04049 2/20 1.00
BRAF P15056 2/20 1.00
PRKACA P17612 2/20 1.00
SLK Q9H2G2 2/20 1.00
KDM4E B2RXH2 1/20 1.00

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Sb-202190 SCHEMBL158854 1.00 MAPK13 (1.00) MAPK13MAPK12MAPK11MAPK14GCGR
SCHEMBL9195650 1.00 MAPK13 (1.00) MAPK13MAPK12MAPK11MAPK14GCGR
Sb-202190 SCHEMBL4893304 0.99 MAPK13 (0.97) MAPK13MAPK12MAPK11MAPK14GCGR
SCHEMBL19868925 0.93 MAPK11 (1.00) MAPK13MAPK12MAPK11MAPK14GCGR
SCHEMBL15075603 0.93 MAPK11 (1.00) MAPK13MAPK12MAPK11MAPK14GCGR
Sb-202190 SCHEMBL6420498 0.89 MAPK13 (0.81) MAPK13MAPK12MAPK11MAPK14GCGR
SCHEMBL28486758 0.87 MAPK14 (1.00) MAPK13MAPK12MAPK11MAPK14GCGR
SCHEMBL4552316 0.87 MAPK14 (1.00) MAPK13MAPK12MAPK11MAPK14GCGR
SCHEMBL6469877 0.87 MAPK14 (1.00) MAPK13MAPK12MAPK11MAPK14GCGR
SCHEMBL2650702 0.87 MAPK11 (1.00) MAPK13MAPK12MAPK11MAPK14GCGR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 40 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20220323376-A1 METHODS AND COMPOSITIONS FOR SENSITIZING CANCER CELLS TO DRUG-INDUCED APOPTOSIS NEW YORK UNIVERSITY 2022-10-13 US claimed
WO-2020223609-A1 METHODS AND COMPOSITIONS FOR SENSITIZING CANCER CELLS TO DRUG-INDUCED APOPTOSIS NEW YORK UNIVERSITY (US) 2020-11-05 WO claimed
EP-2247558-B2 NOVEL IMAGING AGENTS FOR DETECTING NEUROLOGICAL DYSFUNCTION LILLY CO ELI (US) 2024-07-03 EP disclosed
US-20240024490-A1 BIFUNCTIONAL MOLECULES FOR SELECTIVE MODIFICATION OF TARGET SUBSTRATES THE BROAD INSTITUTE, INC. 2024-01-25 US disclosed
US-20230192904-A1 BIFUNCTIONAL CHIMERIC MOLECULES FOR LABELING OF KINASES WITH TARGET BINDING MOIETIES AND METHODS OF USE THEREOF THE BROAD INSTITUTE, INC. 2023-06-22 US disclosed
US-20220323376-A1 METHODS AND COMPOSITIONS FOR SENSITIZING CANCER CELLS TO DRUG-INDUCED APOPTOSIS NEW YORK UNIVERSITY 2022-10-13 US disclosed
EP-2247558-B1 NOVEL IMAGING AGENTS FOR DETECTING NEUROLOGICAL DYSFUNCTION LILLY CO ELI (US) 2022-02-02 EP disclosed
WO-2021086912-A1 COMBINED PIKFYVE AND P38 MAP KINASE INHIBITION FOR TREATING CANCER THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES (US) 2021-05-06 WO disclosed
WO-2020223609-A1 METHODS AND COMPOSITIONS FOR SENSITIZING CANCER CELLS TO DRUG-INDUCED APOPTOSIS NEW YORK UNIVERSITY (US) 2020-11-05 WO disclosed
US-20180055887-A1 METHOD FOR PREPARING INDUCED MESENCHYMAL STEM CELLS AND IMPROVING MESENCHYMAL STEM CELL'S CHARACTERS AND ITS APPLICATIONS ACADEMIA SINICA (TW) 2018-03-01 US disclosed
US-20180055887-A1 METHOD FOR PREPARING INDUCED MESENCHYMAL STEM CELLS AND IMPROVING MESENCHYMAL STEM CELL'S CHARACTERS AND ITS APPLICATIONS ACADEMIA SINICA (TW) 2018-03-01 US disclosed
EP-1592389-A2 PIPERAZINE-2-CARBOXAMIDE DERIVATIVES Applied Research Systems ARS Holding N.V. (AN) 2005-11-09 EP disclosed
US-20050215605-A1 Thiazolidine carboxamide derivatives as modulators of the prostaglandin f receptor MERCK SERONO SA (CH) 2005-09-29 US disclosed
WO-2005044194-A2 TREATMENT OR PREVENTION OF NEOPLASIA BY USE OF AN Hsp90 INHIBITOR PHARMACIA CORPORATION (US) 2005-05-19 WO disclosed
WO-2005041879-A2 COMBINATIONS COMPRISING AN Hsp90 INHIBITOR AND A PHOPHODIESTERASE INHIBITOR FOR TREATING OR PREVENTING NEOPLASIA PHARMACIA CORPORATION (US) 2005-05-12 WO disclosed
EP-1487442-A1 THIAZOLIDINE CARBOXAMIDE DERIVATIVES AS MODULATORS OF THE PROSTAGLANDIN F RECEPTOR Applied Research Systems ARS Holding N.V. (AN) 2004-12-22 EP disclosed
EP-1476840-A2 CRYSTAL STRUCTURES OF JNK-INHIBITOR COMPLEXES AND BINDING POCKETS THEREOF Vertex Pharmaceuticals Incorporated (US) 2004-11-17 EP disclosed
WO-2004071390-A2 PIPERAZINE-2-CARBOXAMIDE DERIVATIVES APPLIED RESEARCH SYSTEMS ARS HOLDING N.V. (AN) 2004-08-26 WO disclosed
WO-2003082278-A1 THIAZOLIDINE CARBOXAMIDE DERIVATIVES AS MODULATORS OF THE PROSTAGLANDIN F RECEPTOR APPLIED RESEARCH SYSTEMS ARS HOLDING N.V. (AN) 2003-10-09 WO disclosed
WO-2003060102-A2 CRYSTAL STRUCTURES OF JNK-INHIBITOR COMPLEXES AND BINDING POCKETS THEREOF VERTEX PHARMACEUTICALS INCORPORATED (US) 2003-07-24 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20220323376-A1 METHODS AND COMPOSITIONS FOR SENSITIZING CANCER CELLS TO DRUG-INDUCED APOPTOSIS MCL1, BAX, CASP3 MAPK13 3801/4885MAPK12 3253/4885MAPK11 3705/4885
US-20240024490-A1 BIFUNCTIONAL MOLECULES FOR SELECTIVE MODIFICATION OF TARGET SUBSTRATES COASY, JMJD7, PTMS MAPK13 2417/4885MAPK12 2705/4885MAPK11 3647/4885
US-20230192904-A1 BIFUNCTIONAL CHIMERIC MOLECULES FOR LABELING OF KINASES WITH TARGET BINDING MOIETIES AND METHODS OF USE THEREOF ERBB2, ACP1, TK1 MAPK13 456/4885MAPK12 653/4885MAPK11 970/4885
US-20180055887-A1 METHOD FOR PREPARING INDUCED MESENCHYMAL STEM CELLS AND IMPROVING MESENCHYMAL STEM CELL'S CHARACTERS AND ITS APPLICATIONS NES, MYADM, CXCL12 MAPK13 3802/4885MAPK12 2913/4885MAPK11 3817/4885
US-20050215605-A1 Thiazolidine carboxamide derivatives as modulators of the prostaglandin f receptor TBXA2R, CNR2, PTGDR MAPK13 3210/4885MAPK12 3145/4885MAPK11 3285/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.