Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 14/20 | 0.75 |
| ▸ | PTGS1 | P23219 | 4/20 | 0.75 |
| ▸ | FAAH | O00519 | 1/20 | 0.58 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.58 |
| ▸ | MAPK14 | Q16539 | 3/20 | 0.57 |
| ▸ | MAPK11 | Q15759 | 2/20 | 0.56 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.56 |
| ▸ | GCGR | P47871 | 1/20 | 0.56 |
| ▸ | MAPK12 | P53778 | 1/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.53 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.53 |
| ▸ | CSNK1A1 | P48729 | 1/20 | 0.53 |
| ▸ | CSNK1D | P48730 | 1/20 | 0.53 |
| ▸ | CSNK1E | P49674 | 1/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.53 |
| ▸ | CSNK1A1L | Q8N752 | 1/20 | 0.53 |
| ▸ | USP1 | O94782 | 1/20 | 0.51 |
| ▸ | USP19 | O94966 | 1/20 | 0.51 |
| ▸ | UCHL3 | P15374 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8553156 | 0.95 | PTGS2 (0.68) | PTGS2PTGS1FAAHKCNH2MAPK14 | |
| SCHEMBL213979 | 0.95 | PTGS2 (0.68) | PTGS2PTGS1FAAHKCNH2MAPK14 | |
| SCHEMBL7504194 | 0.95 | PTGS2 (0.68) | PTGS2PTGS1FAAHKCNH2MAPK14 | |
| SCHEMBL19953600 | 0.86 | PTGS2 (0.75) | PTGS2PTGS1 | |
| SCHEMBL216233 | 0.86 | PTGS2 (1.00) | PTGS2PTGS1 | |
| SCHEMBL7503718 | 0.86 | PTGS2 (1.00) | PTGS2PTGS1 | |
| SCHEMBL1002033 | 0.84 | PTGS2 (0.58) | PTGS2PTGS1FAAHKCNH2MAPK14 | |
| SCHEMBL214222 | 0.82 | PTGS2 (0.70) | PTGS2PTGS1 | |
| SCHEMBL7506192 | 0.81 | PTGS2 (0.67) | PTGS2PTGS1MAPK14MAPK11MAPK13 | |
| SCHEMBL7505884 | 0.81 | PTGS2 (0.67) | PTGS2PTGS1MAPK14MAPK11MAPK13 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1682143-A2 | COMBINATIONS COMPRISING AN HSP90 INHIBITOR AND A PHOPHODIESTERASE INHIBITOR FOR TREATING OR PREVENTING NEOPLASIA | Pharmacia Corporation (US) | 2006-07-26 | — | — | EP | disclosed |
| WO-2005044194-A2 | TREATMENT OR PREVENTION OF NEOPLASIA BY USE OF AN Hsp90 INHIBITOR | PHARMACIA CORPORATION (US) | 2005-05-19 | — | — | WO | disclosed |
| WO-2005041879-A2 | COMBINATIONS COMPRISING AN Hsp90 INHIBITOR AND A PHOPHODIESTERASE INHIBITOR FOR TREATING OR PREVENTING NEOPLASIA | PHARMACIA CORPORATION (US) | 2005-05-12 | — | — | WO | disclosed |