Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 12/20 | 0.68 |
| ▸ | PTGS1 | P23219 | 3/20 | 0.68 |
| ▸ | FAAH | O00519 | 2/20 | 0.57 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.57 |
| ▸ | USP1 | O94782 | 1/20 | 0.53 |
| ▸ | USP19 | O94966 | 1/20 | 0.53 |
| ▸ | UCHL3 | P15374 | 1/20 | 0.53 |
| ▸ | MAPK14 | Q16539 | 3/20 | 0.53 |
| ▸ | MAPK11 | Q15759 | 2/20 | 0.52 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.52 |
| ▸ | GCGR | P47871 | 1/20 | 0.52 |
| ▸ | MAPK12 | P53778 | 1/20 | 0.52 |
| ▸ | LMNA | P02545 | 1/20 | 0.50 |
| ▸ | TSHR | P16473 | 1/20 | 0.50 |
| ▸ | HTT | P42858 | 1/20 | 0.50 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.49 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.49 |
| ▸ | CSNK1A1 | P48729 | 1/20 | 0.49 |
| ▸ | CSNK1D | P48730 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7504194 | 1.00 | PTGS2 (0.68) | PTGS2PTGS1FAAHKCNH2USP1 | |
| SCHEMBL213979 | 1.00 | PTGS2 (0.68) | PTGS2PTGS1FAAHKCNH2USP1 | |
| SCHEMBL5698709 | 0.95 | PTGS2 (0.75) | PTGS2PTGS1FAAHKCNH2USP1 | |
| SCHEMBL7505884 | 0.87 | PTGS2 (0.67) | PTGS2PTGS1USP1USP19UCHL3 | |
| SCHEMBL7506192 | 0.87 | PTGS2 (0.67) | PTGS2PTGS1USP1USP19UCHL3 | |
| SCHEMBL9113400 | 0.86 | MAPK14 (0.61) | PTGS2PTGS1USP1USP19UCHL3 | |
| SCHEMBL7503544 | 0.81 | PTGS2 (0.64) | PTGS2PTGS1 | |
| SCHEMBL7503718 | 0.81 | PTGS2 (1.00) | PTGS2PTGS1 | |
| SCHEMBL216233 | 0.81 | PTGS2 (1.00) | PTGS2PTGS1 | |
| SCHEMBL19953600 | 0.81 | PTGS2 (0.75) | PTGS2PTGS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0825989-A1 | SUBSTITUTED OXAZOLES FOR THE TREATMENT OF INFLAMMATION | G.D. SEARLE & CO. (US) | 1998-03-04 | — | — | EP | disclosed |
| WO-1996036617-A1 | SUBSTITUTED OXAZOLES FOR THE TREATMENT OF INFLAMMATION | G.D. SEARLE & CO. (US) | 1996-11-21 | — | — | WO | disclosed |