⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6470587 | 0.57 | NLRP3 (0.31) | — | |
| SCHEMBL7197021 | 0.56 | — | — | |
| SCHEMBL3170388 | 0.55 | — | — | |
| SCHEMBL36991 | 0.45 | — | — | |
| SCHEMBL11183068 | 0.45 | — | — | |
| SCHEMBL10345890 | 0.43 | — | — | |
| SCHEMBL18893391 | 0.43 | — | — | |
| SCHEMBL6898400 | 0.43 | — | — | |
| SCHEMBL725079 | 0.42 | — | — | |
| SCHEMBL80248 | 0.42 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Appears in 3739 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20210032242-A1 | AROMATIC HETEROCYCLIC SUBSTITUTED OLEFIN COMPOUND, PREPARATION METHOD FOR SAME, PHARMACEUTICAL COMPOSITION OF SAME, AND APPLICATIONS THEREOF | SHANGHAI YINGLI PHARMACEUTICAL CO., LTD (CN) | 2021-02-04 | — | — | US | claimed |
| EP-3013802-B1 | N-CYCLOALKYL-N-[(BICYCLYLPHENYL)METHYLENE]-(THIO)CARBOXAMIDE DERIVATIVES | BAYER CROPSCIENCE AG (DE) | 2019-08-14 | — | — | EP | claimed |
| US-20170362243-A1 | BIARYLETHER IMIDAZOPYRAZINE BTK INHIBITORS | MERCK SHARP & DOHME CORP. (US) | 2017-12-21 | — | — | US | claimed |
| EP-3240545-A1 | BIARYLETHER IMIDAZOPYRAZINE BTK INHIBITORS | Merck Sharp & Dohme Corp. (US) | 2017-11-08 | — | — | EP | claimed |
| US-9770022-B2 | N-cycloalkyl-N-[(bicyclylphenyl)methylene]-(thio)carboxamide derivatives | BAYER CROPSCIENCE AG (DE) | 2017-09-26 | — | — | US | claimed |
| WO-2016109219-A1 | BIARYLETHER IMIDAZOPYRAZINE BTK INHIBITORS | MERCK SHARP & DOHME CORP. (US) | 2016-07-07 | — | — | WO | claimed |
| EP-2836489-B1 | N-ACYL-2-(CYCLO) ALKYLPYRROLIDINES AND PIPERIDINES USEFUL AS FUNGICIDES | BAYER CROPSCIENCE AG (DE) | 2016-06-29 | — | — | EP | claimed |
| US-9357778-B2 | N-acyl-2-(cyclo)alkypyrrolidines and piperidines useful as fungicides | BAYER CROPSCIENCE AG (DE) | 2016-06-07 | — | — | US | claimed |
| US-20160150777-A1 | N-CYCLOALKYL-N-[(BICYCLYLPHENYL)METHYLENE]-(THIO)CARBOXAMIDE DERIVATIVES | BAYER CROPSCIENCE AG (DE) | 2016-06-02 | — | — | US | claimed |
| EP-3013802-A1 | N-CYCLOALKYL-N-[(BICYCLYLPHENYL)METHYLENE]-(THIO)CARBOXAMIDE DERIVATIVES | Bayer Cropscience AG (DE) | 2016-05-04 | — | — | EP | claimed |
| US-6740655-B2 | 3',5'-CYCLIC NUCLEOTIDE PHOSPHODIESTERASE 4-SPECIFIC INHIBITORS REDUCE EOSINOPHIL INFLUX TO THE LUNGS; SIDE EFFECT REDUCTION; ANTIINFLAMMATORY AGENT; ANTIALLERGENS; RESPIRATORY SYSTEM DISORDERS, ESPECIALLY ASTHMA | PFIZER INC | 2004-05-25 | — | — | US | claimed |
| US-20030186989-A1 | Nicotinamide benzofused-heterocyclyl derivatives useful as selective inhibitors of pde4 isozymes | PFIZER INC. | 2003-10-02 | — | — | US | claimed |
| US-20030144300-A1 | Pyrimidine carboxamides useful as inhibitors of pde4 isozymes | PFIZER PRODUCTS INC. | 2003-07-31 | — | — | US | claimed |
| US-20030027845-A1 | Ether derivatives useful as inhibitors of PDE4 isozymes | PFIZER INC. | 2003-02-06 | — | — | US | claimed |
| EP-1252157-A1 | PYRIMIDINE CARBOXAMIDES USEFUL AS INHIBITORS OF PDE4 ISOZYMES | Pfizer Products Inc. (US) | 2002-10-30 | — | — | EP | claimed |
| WO-2001057025-A1 | PYRIMIDINE CARBOXAMIDES USEFUL AS INHIBITORS OF PDE4 ISOZYMES | PFIZER PRODUCTS INC. (US) | 2001-08-09 | — | — | WO | claimed |
| EP-0769489-A1 | Process for the preparation of (bi)cycloalkylanilines | BAYER AG (DE) | 1997-04-23 | — | — | EP | claimed |
| US-4349552-A | TREATMENT OF CANCER | FUJISAWA PHARMACEUTICAL COMPANY, LTD. (JP) | 1982-09-14 | — | — | US | claimed |
| EP-0010941-B1 | 5-FLUOROURACIL DERIVATIVES, PREPARATION THEREOF AND THEIR PHARMACEUTICAL COMPOSITIONS | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1982-05-12 | — | — | EP | claimed |
| EP-0010941-A1 | 5-Fluorouracil derivatives, preparation thereof and their pharmaceutical compositions | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1980-05-14 | — | — | EP | claimed |