SCHEMBL5699458

SCHEMBL5699458

O=C(N[Zr](Cl)(Cl)(NC(=O)c1ccccc1)C1C=Cc2ccccc21)c1ccccc1

nearest known ligand 0.39

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HDAC3 O15379 1/20 0.36
CA12 O43570 1/20 0.36
CA1 P00915 1/20 0.36
IDO1 P14902 1/20 0.36
ALOX15 P16050 1/20 0.36
HDAC1 Q13547 1/20 0.36
CA9 Q16790 1/20 0.36
HDAC7 Q8WUI4 1/20 0.36
HDAC2 Q92769 1/20 0.36
HSD17B10 Q99714 1/20 0.36
HDAC8 Q9BY41 1/20 0.36
HDAC6 Q9UBN7 1/20 0.36
NCOR2 Q9Y618 1/20 0.36
NFKB1 P19838 1/20 0.35
NFKB2 Q00653 1/20 0.35
RELA Q04206 1/20 0.35
ATM Q13315 2/20 0.35
DEPTOR Q8TB45 1/20 0.35
HTT P42858 2/20 0.35
LMNA P02545 2/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5854609 0.83 MEN1 (0.33) HDAC3CA12CA1IDO1ALOX15
SCHEMBL5853044 0.82 ATM (0.32) HDAC3CA12CA1IDO1ALOX15
SCHEMBL436484 0.74 ATM (0.33) ATMMEN1KMT2A
SCHEMBL5856523 0.72 SMN1; SMN2 (0.41) HDAC8HDAC6LMNAMEN1KMT2A
SCHEMBL5854537 0.72 SMN1; SMN2 (0.41) HDAC8HDAC6LMNAMEN1KMT2A
SCHEMBL5853963 0.71 POLB (0.33) LMNAMEN1KMT2ASMN1; SMN2POLB
SCHEMBL5853098 0.71 POLB (0.33) LMNAMEN1KMT2ANPC1RAB9A
SCHEMBL5856493 0.69 MEN1 (0.31) ALOX15MEN1KMT2AMAPTALDH1A1
SCHEMBL5854772 0.69 BRD4 (0.30)
SCHEMBL25418756 0.69 ATM (0.30) ATM

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 18 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1097949-B1 Ethylene/alpha-olefin copolymer and film made therefrom JAPAN POLYCHEM CORP (JP) 2006-08-02 EP disclosed
US-6632911-B1 Blown films of these copolymers are excellent in mechanical characteristics (tensile strength, impact strength, etc.) JAPAN POLYCHEM CORPORATION (JP) 2003-10-14 US disclosed
US-6524985-B1 Organoboroaluminum reaction product of an alkylboronic acid and an alkylaluminum halide, alkylaluminum hydride or alkylaluminum siloxide MITSUBISHI CHEMICAL CORPORATION (JP) 2003-02-25 US disclosed
EP-1097949-A1 Ethylene/alpha-olefin copolymer and film made thereof Japan Polychem Corporation (JP) 2001-05-09 EP disclosed
US-6080827-A Ethylene polymer MITSUBISHI CHEMICAL CORPORATION (JP) 2000-06-27 US disclosed
US-5942459-A ALUMOXANE-FREE MIXTURE OF TRANSITION METAL METALLOCENE, ORGANOALUMINUM COMPOUND, BORIC ACID-CONTAINING POWDER MITSUBISHI CHEMICAL CORPORATION (JP) 1999-08-24 US disclosed
EP-0601830-B1 Catalyst components for polymerization of olefins and use thereof MITSUBISHI CHEM CORP (JP) 1999-07-28 EP disclosed
EP-0728773-B1 Catalysts for olefin polymerization and a process for preparing olefin polymers therewith MITSUBISHI CHEM CORP (JP) 1998-11-04 EP disclosed
EP-0692505-B1 Process for procucing propylene block copolymers MITSUBISHI CHEM CORP (JP) 1998-01-28 EP disclosed
US-5648440-A ALUMINUM-BORON COMPOUND MITSUBISHI CHEMICAL CORPORATION (JP) 1997-07-15 US disclosed
US-5623022-A VAPOR PHASE; USING COORDINATION CATALYST MITSUBISHI CHEMICAL CORPORATION (JP) 1997-04-22 US disclosed
EP-0728773-A1 Catalysts for olefin polymerization and a process for preparing olefin polymers therewith MITSUBISHI CHEMICAL CORPORATION (JP) 1996-08-28 EP disclosed
EP-0589638-B1 Powder catalyst composition and process for polymerizing olefins with the use thereof MITSUBISHI CHEM CORP (JP) 1996-08-14 EP disclosed
EP-0692505-A2 Process for procucing propylene block copolymers MITSUBISHI CHEMICAL CORPORATION (JP) 1996-01-17 EP disclosed
US-5474962-A Powder catalyst composition and process for polymerizing olefins with the use thereof MITSUBISHI PETROCHEMICAL COMPANY LIMITED (JP) 1995-12-12 US disclosed
US-5449650-A Catalyst components for polymerization of olefins and use thereof MITSUBISHI PETROCHEMICAL COMPANY LIMITED (JP) 1995-09-12 US disclosed
EP-0601830-A2 Catalyst components for polymerization of olefins and use thereof MITSUBISHI CHEMICAL CORPORATION (JP) 1994-06-15 EP disclosed
EP-0589638-A2 Powder catalyst composition and process for polymerizing olefins with the use thereof MITSUBISHI CHEMICAL CORPORATION (JP) 1994-03-30 EP disclosed