Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A3 known ✓ | Q01959 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 6/20 | 0.40 |
| ▸ | RECQL | P46063 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.39 |
| ▸ | NPC1 | O15118 | 2/20 | 0.39 |
| ▸ | RAB9A | P51151 | 2/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.39 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 3/20 | 0.37 |
| ▸ | POLB | P06746 | 3/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.37 |
| ▸ | HTT | P42858 | 2/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | AGTR1 | P30556 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5700585 | 0.97 | SMN1; SMN2 (0.42) | SMN1; SMN2RECQLALDH1A1NPC1RAB9A | |
| SCHEMBL5700582 | 0.97 | SMN1; SMN2 (0.42) | SMN1; SMN2RECQLALDH1A1NPC1RAB9A | |
| Hydrochloric Acid SCHEMBL5700353 | 0.92 | LMNA (0.40) | SMN1; SMN2RECQLALDH1A1NPC1RAB9A | |
| SCHEMBL5700600 | 0.92 | SMN1; SMN2 (0.39) | SMN1; SMN2RECQLALDH1A1NPC1RAB9A | |
| SCHEMBL5700405 | 0.89 | LMNA (0.41) | SMN1; SMN2RECQLALDH1A1NPC1RAB9A | |
| SCHEMBL5700407 | 0.89 | LMNA (0.41) | SMN1; SMN2RECQLALDH1A1NPC1RAB9A | |
| Hydrochloric Acid SCHEMBL5700459 | 0.78 | SCN2A (0.51) | SMN1; SMN2ALDH1A1NPC1RAB9ACYP1A2 | |
| SCHEMBL5836703 | 0.74 | SCN2A (0.53) | SMN1; SMN2ALDH1A1NPC1RAB9ACYP1A2 | |
| SCHEMBL26558724 | 0.70 | SMN1; SMN2 (0.40) | SMN1; SMN2ALDH1A1NPC1RAB9ACYP1A2 | |
| SCHEMBL10265496 | 0.69 | LMNA (0.59) | SMN1; SMN2RECQLALDH1A1NPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7141687-B2 | N'-substituted N-acylamidine metal transition complexes and their use as catalysts | BASF AKTIENGESELLSCHAFT (DE) | 2006-11-28 | — | — | US | disclosed |
| EP-1569947-B1 | N'-SUBSTITUTED N-ACYLAMIDINE METAL TRANSITION COMPLEXES AND THEIR USE AS CATALYSTS | BASF AG (DE) | 2006-08-30 | — | — | EP | disclosed |
| US-20060069275-A1 | N'-substituded n-acylamidine metal transition complexes and their use as catalysts | BASF AKTIENGESELLSCHAFT (DE) | 2006-03-30 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060069275-A1 | N'-substituded n-acylamidine metal transition complexes and their use as catalysts | NR1I3, NR0B1, NR4A1 | SLC6A3 756/4885SMN1; SMN2 3235/4885RECQL 1959/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.