Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE10A | Q9Y233 | 2/20 | 0.40 |
| ▸ | OPRM1 | P35372 | 11/20 | 0.37 |
| ▸ | OPRK1 | P41145 | 11/20 | 0.37 |
| ▸ | OPRL1 | P41146 | 11/20 | 0.37 |
| ▸ | OPRD1 | P41143 | 10/20 | 0.37 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.35 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.34 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.34 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.34 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | PABPC1 | P11940 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | NPY1R | P25929 | 1/20 | 0.34 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.34 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5701991 | 0.91 | PDE10A (0.40) | PDE10AOPRM1OPRK1OPRL1OPRD1 | |
| SCHEMBL5464013 | 0.83 | PDE10A (0.41) | PDE10AABCB1SLC6A4KCNH2 | |
| SCHEMBL5702234 | 0.82 | OPRM1 (0.49) | OPRM1OPRK1OPRL1OPRD1FFAR4 | |
| SCHEMBL5463199 | 0.79 | GRIN2B (0.52) | PDE10AFFAR4ABCB1MEN1KMT2A | |
| SCHEMBL5702313 | 0.78 | TACR2 (0.41) | OPRM1OPRK1OPRL1OPRD1ABCB1 | |
| SCHEMBL5702204 | 0.78 | CCR2 (0.32) | OPRM1OPRK1OPRL1OPRD1KCNH2 | |
| SCHEMBL5702215 | 0.76 | ACACB (0.31) | — | |
| SCHEMBL5702082 | 0.75 | OPRL1 (0.35) | OPRM1OPRK1OPRL1OPRD1KCNH2 | |
| SCHEMBL5463189 | 0.74 | TACR2 (0.41) | PDE10AABCB1SLC6A4 | |
| SCHEMBL5462674 | 0.74 | PDE10A (0.41) | PDE10AABCB1MEN1KMT2ASLC6A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1673366-A1 | 1-\"2-(4-HYDROXYPHENYL)-2-HYDROXYETHYL]-PIPERIDIN-4-OL COMPOUNDS AS NMDA RECEPTOR ANTAGONISTS | Pfizer, Inc. (US) | 2006-06-28 | — | — | EP | disclosed |
| WO-2005035522-A1 | 1-‘2-(4-HYDROXYPHENYL)-2-HYDROXYETHYL!-PIPERIDIN-4-OL COMPOUNDS AS NMDA RECEPTOR ANTAGONISTS | PFIZER JAPAN, INC. (JP) | 2005-04-21 | — | — | WO | disclosed |