Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4B | Q07343 | 20/20 | 0.79 |
| ▸ | PDE4A | P27815 | 19/20 | 0.79 |
| ▸ | PDE4C | Q08493 | 19/20 | 0.79 |
| ▸ | PDE4D | Q08499 | 19/20 | 0.79 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5703602 | 1.00 | PDE4B (0.79) | PDE4BPDE4APDE4CPDE4D | |
| SCHEMBL7023689 | 1.00 | PDE4B (0.79) | PDE4BPDE4APDE4CPDE4D | |
| SCHEMBL28381093 | 0.93 | PDE4B (0.92) | PDE4BPDE4APDE4CPDE4D | |
| SCHEMBL7055428 | 0.89 | PDE4B (0.63) | PDE4BPDE4APDE4CPDE4D | |
| SCHEMBL7058059 | 0.89 | PDE4B (0.63) | PDE4BPDE4APDE4CPDE4D | |
| Cilomilast SCHEMBL13777301 | 0.89 | PDE4B (1.00) | PDE4BPDE4APDE4CPDE4D | |
| Cilomilast SCHEMBL26372 | 0.89 | PDE4B (1.00) | PDE4BPDE4APDE4CPDE4D | |
| Cilomilast SCHEMBL27515 | 0.89 | PDE4B (1.00) | PDE4BPDE4APDE4CPDE4D | |
| Cilomilast SCHEMBL27516 | 0.89 | PDE4B (1.00) | PDE4BPDE4APDE4CPDE4D | |
| Cilomilast SCHEMBL5975855 | 0.89 | PDE4B (1.00) | PDE4BPDE4APDE4CPDE4D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0749417-B1 | CYANO COMPOUNDS AND PREPARATIONS THEREOF | SMITHKLINE BEECHAM CORP (US) | 2003-05-07 | — | — | EP | claimed |
| US-6013827-A | Compounds | SMITHKLINE BEECHAM CORPORATION (US) | 2000-01-11 | — | — | US | claimed |
| EP-1849468-A2 | Pharmaceutical composition of a pde4 or a pde3/4 inhibitor and a histamine receptor antagonist | Nycomed GmbH (DE) | 2007-10-31 | — | — | EP | disclosed |
| EP-1279662-B1 | Process for preparing phenylcyclohexan-1-ylcarboxylic acids | SMITHKLINE BEECHAM CORP (US) | 2006-08-16 | — | — | EP | disclosed |
| WO-2004047817-A1 | PDE4 AND PDE3/4 INHIBITORS FOR USE IN THE TREATMENT OF CACHEXIA | ALTANA PHARMA AG (DE) | 2004-06-10 | — | — | WO | disclosed |
| EP-0749417-B1 | CYANO COMPOUNDS AND PREPARATIONS THEREOF | SMITHKLINE BEECHAM CORP (US) | 2003-05-07 | — | — | EP | disclosed |
| WO-2003024488-A2 | COMBINATION OF A PDE INHIBITOR AND A LEUKOTRIENE RECEPTOR ANTAGONIST | ALTANA PHARMA AG (DE) | 2003-03-27 | — | — | WO | disclosed |
| EP-1279662-A1 | Process for preparing phenylcyclohexan-1-ylcarboxylic acids | SmithKline Beecham Corporation (US) | 2003-01-29 | — | — | EP | disclosed |
| US-6013827-A | Compounds | SMITHKLINE BEECHAM CORPORATION (US) | 2000-01-11 | — | — | US | disclosed |
| EP-0749417-A4 | CYANO COMPOUNDS AND PREPARATIONS THEREOF | SMITHKLINE BEECHAM CORP (US) | 1999-04-14 | — | — | EP | disclosed |
| EP-0749417-A1 | CYANO COMPOUNDS AND PREPARATIONS THEREOF | SMITHKLINE BEECHAM CORPORATION (US) | 1996-12-27 | — | — | EP | disclosed |
| WO-1995024381-A1 | CYANO COMPOUNDS AND PREPARATIONS THEREOF | SMITHKLINE BEECHAM CORPORATION (US) | 1995-09-14 | — | — | WO | disclosed |