Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4A | P27815 | 11/20 | 0.57 |
| ▸ | PDE4B | Q07343 | 11/20 | 0.54 |
| ▸ | PDE4D | Q08499 | 11/20 | 0.54 |
| ▸ | PDE4C | Q08493 | 10/20 | 0.54 |
| ▸ | MEN1 | O00255 | 1/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.51 |
| ▸ | NPY1R | P25929 | 1/20 | 0.51 |
| ▸ | NPY2R | P49146 | 1/20 | 0.51 |
| ▸ | POLB | P06746 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL129356 | 0.98 | PDE4A (0.59) | PDE4APDE4BPDE4DPDE4CNPY1R | |
| SCHEMBL130569 | 0.95 | PDE4A (0.55) | PDE4APDE4BPDE4DPDE4CNPY1R | |
| SCHEMBL133005 | 0.91 | PDE4A (0.50) | PDE4APDE4BPDE4DPDE4CNPY1R | |
| SCHEMBL31096114 | 0.91 | PDE4A (0.50) | PDE4APDE4BPDE4DPDE4CNPY1R | |
| SCHEMBL29340248 | 0.88 | NPY1R (0.49) | PDE4APDE4BPDE4DPDE4CMEN1 | |
| SCHEMBL21823754 | 0.84 | PDE4A (0.44) | PDE4APDE4BPDE4DPDE4C | |
| SCHEMBL31096321 | 0.84 | PDE4A (0.44) | PDE4APDE4BPDE4DPDE4C | |
| SCHEMBL682835 | 0.83 | KDM4E (0.44) | PDE4APDE4D | |
| SCHEMBL5823060 | 0.81 | PDE4A (0.77) | PDE4APDE4BPDE4DPDE4CPOLB | |
| SCHEMBL27792295 | 0.81 | NPY1R (0.48) | MEN1KMT2ANPY1RNPY2RPOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-100582088-C | Aminoalcohol derivatives | ASTELLAS PHARMA INC | 2010-01-20 | — | — | CN | disclosed |
| CN-1906154-A | Aminoalcohol derivatives | FUJISAWA PHARMACEUTICAL CO (JP) | 2007-01-31 | — | — | CN | disclosed |
| EP-1697301-A2 | AMINOALCOHOL DERIVATIVES | Astellas Pharma Inc. (JP) | 2006-09-06 | — | — | EP | disclosed |
| WO-2005061433-A2 | AMINOALCOHOL DERIVATIVES | ASTELLAS PHARMA INC. (JP) | 2005-07-07 | — | — | WO | disclosed |