SCHEMBL5704465

SCHEMBL5704465

O=CC(NCc1ccccc1)c1ccc(C(F)(F)F)cc1

nearest known ligand 0.48

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CNR2 P34972 1/20 0.48
SMN1; SMN2 Q16637 3/20 0.44
ALDH1A1 P00352 2/20 0.43
MEN1 O00255 2/20 0.43
KMT2A Q03164 2/20 0.43
GAA P10253 1/20 0.43
MAPT P10636 1/20 0.43
ACP3 P15309 1/20 0.41
KCNH2 Q12809 3/20 0.41
TMEM97 Q5BJF2 3/20 0.41
HSD11B1 P28845 1/20 0.40
CYP1A2 P05177 1/20 0.39
CYP3A4 P08684 1/20 0.39
CYP2C9 P11712 1/20 0.39
TSHR P16473 1/20 0.39
CYP2C19 P33261 1/20 0.39
CCR3 P51677 1/20 0.39
MAPK14 Q16539 1/20 0.39
EPHX2 P34913 1/20 0.39
KDM1A O60341 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Hydrochloric Acid SCHEMBL6480519 0.79 ACP3 (0.45) SMN1; SMN2ALDH1A1ACP3KCNH2CYP1A2
SCHEMBL11984374 0.73 GPBAR1 (0.47) CNR2SMN1; SMN2ALDH1A1MEN1KMT2A
SCHEMBL28387015 0.73 MEN1 (0.54) SMN1; SMN2ALDH1A1MEN1KMT2AGAA
SCHEMBL27091863 0.71 CASR (0.65) SMN1; SMN2ALDH1A1MEN1KMT2AKCNH2
SCHEMBL1515766 0.71 ACP3 (0.54) CNR2ALDH1A1ACP3KCNH2HSD11B1
SCHEMBL8497610 0.70 ALDH1A1 (0.54) SMN1; SMN2ALDH1A1MEN1KMT2AGAA
SCHEMBL18134909 0.70 TACR1 (0.56) CNR2SMN1; SMN2ALDH1A1MEN1KMT2A
SCHEMBL27738446 0.70 FPR2 (0.62) CNR2SMN1; SMN2ALDH1A1MEN1KMT2A
SCHEMBL18807663 0.69 ALDH1A1 (0.50) CNR2SMN1; SMN2ALDH1A1MEN1KMT2A
SCHEMBL9781250 0.69 ALDH1A1 (0.69) ALDH1A1MEN1KMT2AKCNH2TMEM97

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1697304-A1 PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR MODULATORS ELI LILLY AND COMPANY (US) 2006-09-06 EP disclosed
WO-2005054176-A1 PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR MODULATORS ELI LILLY AND COMPANY (US) 2005-06-16 WO disclosed