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Puromycin

Puromycin

SCHEMBL5704567

COc1ccc(C[C@H](N)C(=O)N[C@H]2[C@@H](O)[C@H](n3cnc4c(N(C)C)ncnc43)O[C@@H]2CO)cc1.NC[C@@H]1CC[C@@H](N)[C@@H](O[C@H]2[C@H](O)[C@@H](O[C@H]3O[C@H](CO)[C@@H](O)[C@H](N)[C@H]3O)[C@H](N)C[C@@H]2N)O1

nearest known ligand 0.69

Full drug profile on Sugi Atlas →

Predicted protein targets (top 11)

geneUniProtsupporting neighboursconfidence
▸ NPEPPS P55786 12/20 0.69
▸ ANPEP P15144 10/20 0.69
▸ SMN1; SMN2 Q16637 3/20 0.69
▸ TP53 P04637 2/20 0.69
▸ CYP3A4 P08684 2/20 0.69
▸ LMNA P02545 2/20 0.69
▸ HIF1A Q16665 1/20 0.69
▸ HTT P42858 1/20 0.69
▸ NPC1 O15118 1/20 0.69
▸ RAB9A P51151 1/20 0.69
▸ PAX8 Q06710 1/20 0.69

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Puromycin SCHEMBL13170049 0.83 NPEPPS (1.00) NPEPPSANPEPSMN1; SMN2TP53CYP3A4
Puromycin SCHEMBL18190282 0.83 NPEPPS (1.00) NPEPPSANPEPSMN1; SMN2TP53CYP3A4
Puromycin SCHEMBL21306559 0.83 NPEPPS (1.00) NPEPPSANPEPSMN1; SMN2TP53CYP3A4
Puromycin SCHEMBL12799451 0.83 NPEPPS (1.00) NPEPPSANPEPSMN1; SMN2TP53CYP3A4
Puromycin SCHEMBL20815730 0.83 NPEPPS (1.00) NPEPPSANPEPSMN1; SMN2TP53CYP3A4
Puromycin SCHEMBL24206459 0.83 NPEPPS (1.00) NPEPPSANPEPSMN1; SMN2TP53CYP3A4
Puromycin SCHEMBL21481061 0.83 NPEPPS (1.00) NPEPPSANPEPSMN1; SMN2TP53CYP3A4
Puromycin SCHEMBL22348910 0.83 NPEPPS (1.00) NPEPPSANPEPSMN1; SMN2TP53CYP3A4
Puromycin SCHEMBL22409382 0.83 NPEPPS (1.00) NPEPPSANPEPSMN1; SMN2TP53CYP3A4
Puromycin SCHEMBL14583797 0.83 NPEPPS (1.00) NPEPPSANPEPSMN1; SMN2TP53CYP3A4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1699467-A1 AMINOGLYCOSIDE ANTIBIOTICS FOR USE AS VAP-1/SSAO INHIBITORS Faron Pharmaceuticals OY (FI) 2006-09-13 — — EP disclosed
WO-2005063261-A1 AMINOGLYCOSIDE ANTIBIOTICS FOR USE AS VAP-1/SSAO INHIBITORS FARON PHARMACEUTICALS OY (FI) 2005-07-14 — — WO disclosed
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