Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 3/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.54 |
| ▸ | TSHR | P16473 | 1/20 | 0.54 |
| ▸ | MAPT | P10636 | 1/20 | 0.54 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.54 |
| ▸ | HBB | P68871 | 1/20 | 0.54 |
| ▸ | P2RY6 | Q15077 | 2/20 | 0.52 |
| ▸ | P2RY14 | Q15391 | 2/20 | 0.52 |
| ▸ | NT5E | P21589 | 1/20 | 0.52 |
| ▸ | THRB | P10828 | 1/20 | 0.51 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | PYGM | P11217 | 3/20 | 0.41 |
| ▸ | DNPH1 | O43598 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6536566 | 1.00 | LMNA (0.54) | LMNASMN1; SMN2TSHRMAPTPMP22 | |
| SCHEMBL1055675 | 0.92 | LMNA (0.58) | LMNASMN1; SMN2TSHRMAPTPMP22 | |
| SCHEMBL2583193 | 0.92 | LMNA (0.58) | LMNASMN1; SMN2TSHRMAPTPMP22 | |
| SCHEMBL7800239 | 0.91 | P2RY6 (0.54) | LMNASMN1; SMN2TSHRMAPTPMP22 | |
| SCHEMBL10895353 | 0.89 | LMNA (0.56) | LMNASMN1; SMN2TSHRMAPTPMP22 | |
| SCHEMBL10894860 | 0.89 | LMNA (0.50) | LMNASMN1; SMN2TSHRMAPTPMP22 | |
| SCHEMBL10894855 | 0.89 | LMNA (0.50) | LMNASMN1; SMN2TSHRMAPTPMP22 | |
| SCHEMBL10887395 | 0.89 | LMNA (0.50) | LMNASMN1; SMN2TSHRMAPTPMP22 | |
| SCHEMBL10887401 | 0.89 | LMNA (0.50) | LMNASMN1; SMN2TSHRMAPTPMP22 | |
| SCHEMBL8160426 | 0.88 | LMNA (0.52) | LMNASMN1; SMN2THRBHIF1AALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2601202-A1 | BONE-TARGETING BISPHOSPHONATE DUPLEX DRUGS | SCHOTT, Herbert (DE) | 2013-06-12 | — | — | EP | disclosed |
| WO-2012016994-A1 | BONE-TARGETING BISPHOSPHONATE DUPLEX DRUGS | SCHOTT HERBERT (DE) | 2012-02-09 | — | — | WO | disclosed |