Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HAO1 | Q9UJM8 | 2/20 | 0.50 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.50 |
| ▸ | MAP2K4 | P45985 | 1/20 | 0.50 |
| ▸ | MAPKAPK2 | P49137 | 1/20 | 0.50 |
| ▸ | MAPK6 | Q16659 | 1/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.45 |
| ▸ | YTHDC1 | Q96MU7 | 1/20 | 0.45 |
| ▸ | STAT3 | P40763 | 1/20 | 0.45 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.45 |
| ▸ | CTNNB1 | P35222 | 1/20 | 0.44 |
| ▸ | WNT3A | P56704 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | FLT3 | P36888 | 4/20 | 0.43 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.43 |
| ▸ | CDK2 | P24941 | 1/20 | 0.43 |
| ▸ | CCNA1 | P78396 | 1/20 | 0.43 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.43 |
| ▸ | MAP4K1 | Q92918 | 1/20 | 0.43 |
| ▸ | IDO1 | P14902 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL9444673 | 0.98 | HAO1 (0.49) | HAO1MAPK1MAP2K4MAPKAPK2MAPK6 | |
| SCHEMBL3779528 | 0.85 | MAP2K4 (0.49) | HAO1MAPK1MAP2K4MAPKAPK2MAPK6 | |
| SCHEMBL2723270 | 0.85 | MAP2K4 (0.49) | HAO1MAPK1MAP2K4MAPKAPK2MAPK6 | |
| SCHEMBL1967918 | 0.81 | GPR17 (0.43) | HAO1MAPK1MAP2K4MAPK6KDM4E | |
| SCHEMBL28497966 | 0.81 | PARP1 (0.45) | HAO1MAPK1MAP2K4MAPK6KDM4E | |
| SCHEMBL28503102 | 0.79 | PARP1 (0.44) | HAO1MAPK1MAP2K4MAPK6KDM4E | |
| SCHEMBL7374273 | 0.79 | GAA (0.54) | MAP2K4HCAR2 | |
| SCHEMBL28192986 | 0.79 | MAPK1 (0.54) | HAO1MAPK1MAP2K4MAPKAPK2MAPK6 | |
| SCHEMBL16240884 | 0.79 | CTNNB1 (0.44) | KDM4EYTHDC1STAT3HIF1ACTNNB1 | |
| SCHEMBL492585 | 0.79 | CTNNB1 (0.48) | MAPKAPK2KDM4ESTAT3HIF1ACTNNB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 25 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007054784-A1 | AN IMPROVED PROCESS FOR THE PREPARATION OF GRANISETRON HYDROCHLORIDE | ORCHID CHEMICALS & PHARMACEUTICALS LIMITED (IN) | 2007-05-18 | — | — | WO | claimed |
| CN-1260216-C | Method for synthesizing 1-methyl-benzdiazole-3-formic acid | UNIV WUHAN (CN) | 2006-06-21 | — | — | CN | claimed |
| EP-0772613-A2 | PROCESS FOR THE PRODUCTION OF AMINOAZOBICYCLOALKANES FROM OXIMES | SMITHKLINE BEECHAM PLC (GB) | 1997-05-14 | — | — | EP | claimed |
| WO-1996003401-A2 | PROCESS FOR THE PRODUCTION OF AMINOAZOBICYCLOALKANES FROM OXIMES | SMITHKLINE BEECHAM PLC (GB) | 1996-02-08 | — | — | WO | claimed |
| CN-109796410-A | A kind of synthetic method of 5- substituted indazole -3- carboxylic acid | 药雅科技(上海)有限公司 | 2019-05-24 | — | — | CN | disclosed |
| US-20190040016-A1 | INDOLE AND INDAZOLE COMPOUNDS AND THERAPEUTIC USES THEREOF | REGENTS OF THE UNIVERSITY OF MINNESOTA | 2019-02-07 | — | — | US | disclosed |
| EP-3433235-A1 | INDOLE AND INDAZOLE COMPOUNDS AND THERAPEUTIC USES THEREOF | Regents of the University of Minnesota (US) | 2019-01-30 | — | — | EP | disclosed |
| WO-2017165300-A1 | INDOLE AND INDAZOLE COMPOUNDS AND THERAPEUTIC USES THEREOF | REGENTS OF THE UNIVERSITY OF MINNESOTA (US) | 2017-09-28 | — | — | WO | disclosed |
| CN-105061313-B | Androgen receptor modulating compounds | 奥赖恩公司 | 2017-07-18 | — | — | CN | disclosed |
| EP-2812346-A1 | LIGANDS FOR ANTIBODY AND FC-FUSION PROTEIN PURIFICATION BY AFFINITY CHROMOTOGRAPHY IV | Graffinity Pharmaceuticals GmbH (DE) | 2014-12-17 | — | — | EP | disclosed |
| EP-2651906-A1 | INHIBITORS OF HEPATITIS C VIRUS POLYMERASE | Cocrystal Discovery, Inc. (US) | 2013-10-23 | — | — | EP | disclosed |
| WO-2013117707-A1 | LIGANDS FOR ANTIBODY AND FC-FUSION PROTEIN PURIFICATION BY AFFINITY CHROMOTOGRAPHY IV | GRAFFINITY PHARMACEUTICALS GMBH (DE) | 2013-08-15 | — | — | WO | disclosed |
| EP-2170874-A2 | NOVEL COMPOUNDS AND THEIR USE | Orchid Research Laboratories Limited (IN) | 2010-04-07 | — | — | EP | disclosed |
| WO-2009001192-A2 | NOVEL COMPOUNDS AND THEIR USE | ORCHID RESEARCH LABORATORIES LIMITED (IN) | 2008-12-31 | — | — | WO | disclosed |
| WO-2007088557-A1 | PROCESS FOR HIGHLY PURE CRYSTALLINE GRANISETRON BASE | NATCO PHARMA LIMITED (IN) | 2007-08-09 | — | — | WO | disclosed |
| EP-1487833-A1 | PROCESS FOR PREPARING A PHARMACEUTICALLY ACTIVE COMPOUND (GRANISETRON) | LABORATORIOS VITA, S.A. (ES) | 2004-12-22 | — | — | EP | disclosed |
| WO-2003080606-A1 | PROCESS FOR PREPARING A PHARMACEUTICALLY ACTIVE COMPOUND (GRANISETRON) | LABORATORIOS VITA, S.A. (ES) | 2003-10-02 | — | — | WO | disclosed |
| US-5331006-A | Cholecystokinin, antisecretory agents | WARNER-LAMBERT COMPANY (US) | 1994-07-19 | — | — | US | disclosed |
| EP-0528026-A1 | NEW MESO-AZACYCLIC AROMATIC ACID AMIDES AND ESTERS AS NOVEL SEROTONERGIC AGENTS | G.D. SEARLE & CO. (US) | 1993-02-24 | — | — | EP | disclosed |
| WO-1992004025-A1 | AMINO ACID ANALOGS AS CCK ANTAGONISTS | WARNER-LAMBERT COMPANY (US) | 1992-03-19 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20190040016-A1 | INDOLE AND INDAZOLE COMPOUNDS AND THERAPEUTIC USES THEREOF | INMT, IDO1, IDO2 | HAO1 3843/4885MAPK1 4250/4885MAP2K4 2387/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.