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Tryptophan

Tryptophan

SCHEMBL5705407

CC(C)[C@H](N)C(=O)O.NC(=O)CC[C@H](N)C(=O)O.NC(=O)CC[C@H](N)C(=O)O.NCCCC[C@H](N)C(=O)O.NCCCC[C@H](N)C(=O)O.N[C@@H](CO)C(=O)O.N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O.N[C@@H](Cc1ccc(O)cc1)C(=O)O.N[C@@H](Cc1ccccc1)C(=O)O.O=C(O)[C@@H]1CCCN1

nearest known ligand 0.46

Full drug profile on Sugi Atlas →

Known targets — ChEMBL curated mechanism

PPARDPTGS1PTGS2dacAdacBdacCftsImrcAmrcBmrdA

The experimentally established mechanism targets of Tryptophan. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.

Predicted protein targets (top 11)

geneUniProtsupporting neighboursconfidence
▸ GHSR Q92847 2/20 0.46
▸ KDM4E B2RXH2 1/20 0.40
▸ MEN1 O00255 1/20 0.40
▸ LMNA P02545 1/20 0.40
▸ MPO P05164 1/20 0.40
▸ MAPT P10636 1/20 0.40
▸ TSHR P16473 1/20 0.40
▸ BLM P54132 1/20 0.40
▸ PMP22 Q01453 1/20 0.40
▸ KMT2A Q03164 1/20 0.40
▸ HIF1A Q16665 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Tryptophan SCHEMBL8508162 0.97 GHSR (0.48) GHSRKDM4EMEN1LMNAMPO
Dl-Tryptophan SCHEMBL28993572 0.88 KDM4E (0.52) KDM4EMEN1LMNAMPOMAPT
Tryptophan SCHEMBL28755030 0.87 GHSR (0.42) GHSRMEN1KMT2A
Tryptophan SCHEMBL27785017 0.86 GHSR (0.50) GHSRKDM4EMEN1LMNAMPO
Tryptophan SCHEMBL28607194 0.86 GHSR (0.48) GHSRKDM4EMEN1LMNAMPO
Dl-Tryptophan SCHEMBL27657599 0.85 KDM4E (0.48) GHSRKDM4EMEN1LMNAMPO
Tryptophan SCHEMBL27620479 0.85 GHSR (0.44) GHSRMEN1KMT2A
Tryptophan SCHEMBL6480796 0.85 MEN1 (0.41) KDM4EMEN1LMNAMPOMAPT
Tryptophan SCHEMBL9641499 0.85 GHSR (0.49) GHSRKDM4EMEN1LMNAMPO
Tryptophan SCHEMBL6437302 0.85 GHSR (0.41) GHSRMEN1KMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0912718-B1 METHOD FOR PROTEIN STABILISATION OF WINES APPLIC DE RECH S ET DE CONSEIL (FR) 2006-09-20 — — EP disclosed
US-6238880-B1 Method for protein stabilization of wines SOCIETE D'APPLICATIONS DE RECHERCHES ET DE CONSEILS OENOLOGIQUES (FR) 2001-05-29 — — US disclosed