Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MGLL | Q99685 | 3/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | BCL2 | P10415 | 3/20 | 0.38 |
| ▸ | BCL2L1 | Q07817 | 3/20 | 0.38 |
| ▸ | HSD11B1 | P28845 | 4/20 | 0.38 |
| ▸ | MAPT | P10636 | 2/20 | 0.37 |
| ▸ | CCR1 | P32246 | 2/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | TP53 | P04637 | 1/20 | 0.37 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.37 |
| ▸ | RELA | Q04206 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | IDO1 | P14902 | 1/20 | 0.37 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.36 |
| ▸ | FFAR2 | O15552 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL570865 | 0.83 | MGLL (0.42) | MGLLMEN1KMT2ABCL2BCL2L1 | |
| SCHEMBL553728 | 0.83 | MEN1 (0.50) | MEN1KMT2AIDO1 | |
| SCHEMBL553729 | 0.83 | MEN1 (0.50) | MEN1KMT2AIDO1 | |
| SCHEMBL554530 | 0.83 | MEN1 (0.50) | MEN1KMT2AIDO1 | |
| SCHEMBL31450899 | 0.83 | MEN1 (0.50) | MEN1KMT2AIDO1 | |
| SCHEMBL554396 | 0.82 | BCL2L1 (0.46) | BCL2BCL2L1LMNA | |
| SCHEMBL31450836 | 0.82 | BCL2L1 (0.46) | BCL2BCL2L1LMNA | |
| SCHEMBL31451040 | 0.82 | BCL2L1 (0.46) | BCL2BCL2L1LMNA | |
| SCHEMBL553748 | 0.82 | BCL2L1 (0.46) | BCL2BCL2L1LMNA | |
| SCHEMBL553747 | 0.82 | BCL2L1 (0.46) | BCL2BCL2L1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2601177-A1 | N-ACYLSULFONAMIDE APOPTOSIS PROMOTERS | AstraZeneca AB (SE) | 2013-06-12 | — | — | EP | disclosed |
| WO-2012017251-A1 | N-ACYLSULFONAMIDE APOPTOSIS PROMOTERS | ASTRAZENECA AB (SE) | 2012-02-09 | — | — | WO | disclosed |