Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 4/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.47 |
| ▸ | EPHX1 | P07099 | 4/20 | 0.46 |
| ▸ | CNR1 | P21554 | 2/20 | 0.45 |
| ▸ | EPHX2 | P34913 | 4/20 | 0.43 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 2/20 | 0.42 |
| ▸ | HTT | P42858 | 2/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | TP53 | P04637 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | IDH1 | O75874 | 2/20 | 0.42 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5706001 | 0.87 | EPHX1 (0.49) | MEN1KMT2AEPHX1CNR1EPHX2 | |
| SCHEMBL5705940 | 0.85 | MEN1 (0.52) | MEN1KMT2ACNR1EPHX2MCHR1 | |
| SCHEMBL4106239 | 0.85 | MCHR1 (0.52) | MEN1KMT2AEPHX1CNR1EPHX2 | |
| SCHEMBL5705917 | 0.82 | CNR1 (0.57) | MEN1KMT2ACNR1EPHX2MCHR1 | |
| SCHEMBL4119232 | 0.81 | CNR1 (0.50) | MEN1KMT2AEPHX1CNR1LMNA | |
| SCHEMBL4124705 | 0.81 | EPHX1 (0.51) | MEN1KMT2AEPHX1CNR1EPHX2 | |
| SCHEMBL4114482 | 0.81 | EPHX1 (0.51) | MEN1KMT2AEPHX1CNR1EPHX2 | |
| SCHEMBL4124710 | 0.80 | PKM (0.50) | KMT2ACNR1EPHX2MCHR1LMNA | |
| SCHEMBL4128421 | 0.79 | EPHX2 (0.55) | KMT2ACNR1EPHX2MCHR1TP53 | |
| SCHEMBL4116381 | 0.78 | MCHR1 (0.58) | MEN1KMT2ACNR1MCHR1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1711175-A1 | DIUREA DERIVATIVES | Active Biotech AB (SE) | 2006-10-18 | — | — | EP | claimed |
| WO-2005074919-A1 | DIUREA DERIVATIVES | ACTIVE BIOTECH AB (SE) | 2005-08-18 | — | — | WO | claimed |
| EP-1711175-A1 | DIUREA DERIVATIVES | Active Biotech AB (SE) | 2006-10-18 | — | — | EP | disclosed |
| WO-2005074919-A1 | DIUREA DERIVATIVES | ACTIVE BIOTECH AB (SE) | 2005-08-18 | — | — | WO | disclosed |