Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FFAR1 | O14842 | 11/20 | 0.38 |
| ▸ | RXRA | P19793 | 1/20 | 0.37 |
| ▸ | RXRB | P28702 | 1/20 | 0.37 |
| ▸ | RXRG | P48443 | 1/20 | 0.37 |
| ▸ | CYP26A1 | O43174 | 4/20 | 0.34 |
| ▸ | CYP26B1 | Q9NR63 | 2/20 | 0.34 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.34 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.34 |
| ▸ | FPR1 | P21462 | 1/20 | 0.34 |
| ▸ | FPR3 | P25089 | 1/20 | 0.34 |
| ▸ | GPR183 | P32249 | 1/20 | 0.34 |
| ▸ | APLNR | P35414 | 1/20 | 0.34 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.34 |
| ▸ | GPR65 | Q8IYL9 | 1/20 | 0.34 |
| ▸ | RARA | P10276 | 1/20 | 0.33 |
| ▸ | RARB | P10826 | 1/20 | 0.33 |
| ▸ | RARG | P13631 | 1/20 | 0.33 |
| ▸ | FDFT1 | P37268 | 1/20 | 0.32 |
| ▸ | SLC22A12 | Q96S37 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5706373 | 0.87 | FFAR1 (0.40) | FFAR1RXRACYP26A1CYP26B1FFAR4 | |
| SCHEMBL4520154 | 0.76 | RARA (0.42) | FFAR1RXRARXRBRXRGCYP26A1 | |
| SCHEMBL4515574 | 0.73 | RXRA (0.41) | FFAR1RXRARXRBRXRGCYP26A1 | |
| SCHEMBL9180549 | 0.70 | CYP26A1 (0.43) | FFAR1RXRARXRBRXRGCYP26A1 | |
| SCHEMBL9817713 | 0.67 | RARA (0.49) | FFAR1RXRARXRBRXRGCYP26A1 | |
| SCHEMBL9817887 | 0.67 | RXRA (0.41) | FFAR1RXRARXRBRXRGCYP26A1 | |
| SCHEMBL7660646 | 0.67 | FFAR1 (0.40) | FFAR1RXRARXRBRXRGCYP26A1 | |
| SCHEMBL4508439 | 0.67 | RARA (0.41) | RARARARBRARGFDFT1 | |
| SCHEMBL7637513 | 0.65 | RARA (0.46) | CYP26A1RARARARBRARG | |
| SCHEMBL4510053 | 0.65 | FFAR1 (0.40) | FFAR1RXRARXRBRXRGCYP26A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1696899-A1 | METHODS FOR TREATING RETINOID RESPONSIVE DISORDERS USING SELECTIVE INHIBITORS OF CYP26A AND CYP26B | ALLERGAN, INC. (US) | 2006-09-06 | — | — | EP | disclosed |
| WO-2005058301-A1 | METHODS FOR TREATING RETINOID RESPONSIVE DISORDERS USING SELECTIVE INHIBITORS OF CYP26A AND CYP26B | ALLERGAN, INC. (US) | 2005-06-30 | — | — | WO | disclosed |